Muscular Dystrophies

by Robert C. Griggs MD, FACP, FAAN (Editor), Anthony A. Amato MD (Editor)

Overview

The Handbook of Clinical Neurology Vol 101: Muscular Dystrophies discusses the pathogenesis and treatment prospects for muscular dystrophies. It summarizes the advances in molecular and cell biology, biochemistry, and other biological sciences, with an emphasis on their application to this group of muscle disorders and to their clinical implications.

Starting with an overview of muscular dystrophies, the book’s 16 chapters discuss dystrophinopathies; sarcoglycanopathies; congenital muscular dystrophies; collagen VI-related myopathies; limb-girdle muscular dystrophy 2A; dysferlinopathies; limb-girdle muscular dystrophy 2H and the role of TRIM32; and caveolinopathies. The book also covers myofibrillar myopathies; Emery–Dreifuss muscular dystrophy; facioscapulohumeral dystrophy and scapuloperoneal syndromes; oculopharyngeal muscular dystrophy; myotonic dystrophy types 1 and 2; and distal muscular dystrophies.

This book is useful to basic investigators, as it offers an increased understanding of muscular dystrophies; and to clinicians, with its emphasis on issues that are relevant to the care, diagnosis, and management of patients with these disorders.

• Valuable insights into the muscular dystrophies, including treatment, diagnosis, and care and patient management
• A comprehensive compilation of the combined wisdom of the most highly regarded physicians, experts, and scientists studying the muscular dystrophies
• An evaluation of the way advances in molecular and cell biology, biochemistry, and other biological sciences continue to advance the study of these disorders

Product Details

ISBN-13:	9780444534897
Publisher:	Elsevier Science
Publication date:	05/24/2011
Series:	ISSN , #101
Sold by:	Barnes & Noble
Format:	eBook
Pages:	284
File size:	12 MB
Note:	This product may take a few minutes to download.

Table of Contents

Chapter 1: Overview of the muscular dystrophies

Chapter 2: Dystrophinopathies

Chapter 3: Sarcoglycanopathies

Chapter 4: Congenital muscular dystrophies

Chapter 5: The collagen VI-related myopathies

Chapter 6: Limb-girdle muscular dystrophy 2A

Chapter 7: Dysferlinopathies

Chapter 8: Other limb-girdle muscular dystrophies

Chapter 9: Limb-girdle muscular dystrophy 2H and the role of TRIM32

Chapter 10: Caveolinopathies

Chapter 11: Myofibrillar myopathies

Chapter 12: Emery–Dreifuss muscular dystrophy

Chapter 13: Facioscapulohumeral dystrophy and scapuloperoneal syndromes

Chapter 14: Oculopharyngeal muscular dystrophy

Chapter 15: Myotonic dystrophy types 1 and 2

Chapter 16: Distal muscular dystrophies

What People are Saying About This

From the Publisher

This volume is part of the Handbook of Clinical Neurology series, the world’s most comprehensive source of information in neurology. Now in its third generation, the series has an unparalleled reputation for providing the latest foundational research, diagnosis, and treatment protocols essential for both basic neuroscience research and clinical neurology

Editorial Reviews

Reviewer: Ales Hlubocky, MD (Mayo Clinic Arizona)
Description: This succinct and remarkable book on muscular dystrophies reflects the latest expert opinions and a major development in our understanding of these heterogeneous disorders, hopefully laying the foundation for future successful therapies.
Purpose: The purpose is to present a summary of what we know and new insights into these disorders with an emphasis on advances in molecular and cell biology, biochemistry, and other biological sciences and their clinical implications as well as their relevance to the diagnosis and management of patients. These important and worthy objectives are expertly met in this book, part of the Handbook of Clinical Neurology series.
Audience: The editors have assembled an impressive international group of renowned neuromuscular experts to write this book. Although it targets basic investigators and clinicians in general, it will benefit neuromuscular specialists, neurologists, neurology residents, and fellows the most.
Features: Taking into account the dilemma of the ingrained terminology and incompleteness of traditional classifications based on age of onset, mode of inheritance, and pattern of weakness for these disorders, the authors include the nomenclature stemming from the genetic defect such as dystrophinopathies, sarcoglycanopathies, the collagen VI-related myopathies, dysferlinopathies, caveolinopathies, etc. Chapters provide cogent summaries of each of these muscular dystrophy subtypes with sections that highlight a logical approach that includes information not only on background, epidemiology, pathology, pathophysiology, but also the recommended diagnostic algorithms, management, prognosis, and research, along with hopes for future causative therapies. The tables, diagrams, and figures are well designed, easy to understand, and demonstrate the take-home message with clarity. Although some illustrations are in color, there is room for more of these as they significantly liven up the text and enhance readers' experience.
Assessment: This is a high quality resource for the targeted audience that pays special attention to rapid developments and the latest information in the field of neuromuscular neurology while providing a practical approach to the diagnosis and management of these disorders. It competes well with other books on this topic and, in some areas, surpasses them.

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