Neurobiology of Addiction / Edition 1 available in Hardcover, eBook
Neurobiology of Addiction / Edition 1
- ISBN-10:
- 0124192394
- ISBN-13:
- 9780124192393
- Pub. Date:
- 11/29/2005
- Publisher:
- Elsevier Science
- ISBN-10:
- 0124192394
- ISBN-13:
- 9780124192393
- Pub. Date:
- 11/29/2005
- Publisher:
- Elsevier Science
Neurobiology of Addiction / Edition 1
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Overview
The book incorporates diverse finding with an emphasis on integration and synthesis rather than discrepancies or differences in the literature.
Product Details
ISBN-13: | 9780124192393 |
---|---|
Publisher: | Elsevier Science |
Publication date: | 11/29/2005 |
Edition description: | New Edition |
Pages: | 504 |
Product dimensions: | 8.50(w) x 10.88(h) x (d) |
About the Author
Dr. Koob's research interests have been directed at the neurobiology of emotion, with a focus on the theoretical constructs of reward and stress. He has made contributions to our understanding of the anatomical connections of the emotional systems and the neurochemistry of emotional function. Dr. Koob has identified afferent and efferent connections of the basal forebrain (extended amygdala) in the region of the nucleus accumbens, bed nucleus of the stria terminalis, and central nucleus of the amygdala in motor activation, reinforcement mechanisms, behavioral responses to stress, drug self-administration, and the neuroadaptation associated with drug dependence.
Dr. Koob also is one of the world's authorities on the neurobiology of drug addiction. He has contributed to our understanding of the neurocircuitry associated with the acute reinforcing effects of drugs of abuse and more recently on the neuroadaptations of these reward circuits associated with the transition to dependence. He has validated key animal models for dependence associated with drugs of abuse and has begun to explore a key role of anti-reward systems in the development of dependence.
Dr. Koob's work with the neurobiology of stress includes the characterization of behavioral functions in the central nervous system for catecholamines, opioid peptides, and corticotropin-releasing factor. Corticotropin-releasing factor, in addition to its classical hormonal functions in the hypothalamic-pituitary-adrenal axis, is also located in extrahypothalamic brain structures and may have an important role in brain emotional function. Recent use of specific corticotropin-releasing factor antagonists suggests that endogenous brain corticotropin-releasing factor may be involved in specific behavioral responses to stress, the psychopathology of anxiety and affective disorders, and drug addiction.
Michel Le Moal, M.D., is Professor Emeritus of Neuroscience at the University of Bordeaux, France. He graduated in Medicine (1962) in Philosophy-Sociology and Natural Science and then Neurology (1967) and Psychiatry (1968). He completed a Doctoral in Science at the University of Bordeaux in 1974. In parallel with his academic life in Bordeaux, he spent time as an Associate Researcher and Professor at Caltech (1974) and at The Salk Institute and The Scripps Research Institute. At both institutions, he worked on dopamine neuron electrophysiology and investigated the roles of brain CRF and dopamine systems in behavior and drug addiction. He research interests concern behavior and adaptive processes, their biological foundations, and experimental psychopathology, a discipline he promoted. The concept of individual vulnerability to behavioral pathologies has been at the center of his working hypothesis. Dr. Le Moal has been the founder and director of several research laboratories at the Centre National de la Recherche Scientifique (CNRS) and Institut National de la Sante et de la Recherche Medicale and finally the Magendie Institute for Neuroscience and Biological Psychiatry in Bordeaux, France. He is an elected Fellow of the French National Academy of Sciences.
Table of Contents
1. What is Addiction.2. Animal Models of Drug Addiction.
3. Psychostimulants.
4. Opioids.
5. Alcohol.
6. Nicotine.
7. Cannabinoids.
8. Imaging.
9. Neurobiological Theories of Addiction.
10. Drug Addiction: Transition from Neuroadaptation to Pathophysiology.
What People are Saying About This
A thorough review of the extant work on the neurobiology of addiction.