New Concepts in Cerebral Ischemia

by Rick C. S. Lin (Editor)

Overview

Approximately half a million Americans suffer brain ischemic episodes every year. These brain strokes are the third leading cause of death in the United States and the number-one cause of permanent disability. Over the past decade, we have made extensive attempts to understand the biological mechanisms that underlie stroke-induced neuronal injury. Providing a detailed description of the techniques and theories employed in both basic and clinical research, New Concepts in Cerebral Ischemia delineates the mechanisms underlying neuronal damage induced by ischemia. The book covers methods to elucidate the pathogenesis of ischemia, technologies used in the design of specific strategies to protect neurons from further injury, and new approaches to treat patients with acute ischemic episodes. It includes methods and therapeutic approaches for neuronal protection against acute and chronic ischemic episodes and describes new animal models for ischemia research including the application of transgenic animals.

Product Details

ISBN-13:	9781040202326
Publisher:	CRC Press
Publication date:	12/21/2001
Series:	Frontiers in Neuroscience
Sold by:	Barnes & Noble
Format:	eBook
Pages:	328
File size:	5 MB

About the Author

Rick C. S. Lin

Table of Contents

Gender Differences in Post-Ischemic and Post-Traumatic Brain Injury. Neonatal Hypoxic-Ischemic Insults and Its Mechanism. Neural Stem Cell Biology Provides Insights into New Therapeutic Strategies for Hypoxic-Ischemic Brain-Injury. Cellular and Molecular Mechanisms of Ischemic Tolerance. Excitotoxicity, Oxidative Stress, and Apoptosis in Ischemic Neuronal Death. Immediate and delayed Factors Causing Neuronal Death after Ischemic and Excitotoxic Insults. Mechanism of Zinc-Induced Neuronal Death. Cerebral Ischemia and Adenosine. Calpain and Caspase in Ischemic and Traumatic Brain Injury. The Potential Role of Hyperbaric Oxygen Therapy as an Adjunctive Treatment Modality for Stroke. Brain Inflammation, Cytokines, and p38AP Kinase Signaling in Stroke.

Editorial Reviews

Contributors from neuroscience, pharmacology, and other medical specialties offer detailed descriptions of the various mechanisms involved in neuronal degeneration and the glial response to stroke and/or traumatic brain injury, emphasizing potential strategies that may prove beneficial for neuroprotection following ischemic insult or a damage-induced event. Among the topics are gender differences in acute cerebral ischemia and the neuroprotective mechanisms of estrogen, insights from neural stem cell biology into new therapeutic strategies for hypoxic-ischemic brain injury, the mechanism of zinc- induced neuronal death, and the potential role of hyperbaric oxygen in treating stroke. Annotation c. Book News, Inc., Portland, OR (booknews.com)