There is a unique nutritional commonality developing in research relating to coronary heart disease and cancer. The primary aim of this conference was to provide a forum for the leading researchers, clinicians, educators and administrators in these two fields to present a program on heart disease and cancer which included a) the major historical milestones, b) the present areas of greatest interest in research and therapy, c) the latest nutritional, molecular, and biotechnological advances, and d) a perspective on the most promising areas for future research and therapy. Scientists have long contended that research marches on the feet of methodology. Thus there are numerous examples of research fields opening secondary to methodological advances. Some examples are: 1) thin layer and gas-liquid chromatography which, along with high pressure liquid chromatography have broadened the line of advances in lipid research and 2) peR and the resultant impact on molecular biological approaches to several fields of science. The organizers of this conference thought the time was propitious for bringing together knowledge on newer aspects of molecular biological research with current advances in the two major areas of degenerative disease--coronary heart disease and cancer. Our knowledge of these "killer diseases" has expanded greatly in the past few years and the advance has been catalyzed by use of an array of molecular biological techniques. Thanks to these, medical thinking in these areas is changing from considerations of treatment to strategies for prevention.
Table of ContentsHeart Disease.- Historical Review of Research on Atherosclerosis.- Nutrition and Coronary Heart Disease Epidemiology.- Obesity, Fat Patterning and Cardiovascular Risk.- The Role of Lipoproteins in Atherogenesis.- Role of Oxidized LDL and Antioxidants in Atherosclerosis.- Signal Transduction in Atherosclerosis: Second Messengers and Regulation of Cellular Cholesterol Trafficking.- Genetic Determinants of Myocardial Infarction.- Gene Therapy in Heart Disease.- Possible Role of Viruses in Atherosclerosis.- Impact of Biotechnology in the Diagnostic and Therapeutic Management of Cardiovascular Disorders.- Cancer.- Nutrition and Carcinogenesis: Historical Highlights and Future Prospects.- Epidemiology of Anticarcinogens in Food.- Dietary Effects on DNA Methylation: Do They Account for the Hepatocarcinogenic Properties of Lipotrope Deficient Diets?.- Cholesterol, Cholesterogenesis and Cancer.- Inhibition of the Induction of Cancer by Antioxidants.- Nutrients, Signal Transduction and Carcinogenesis.- Nutrition, Immunology and Cancer: An Overview.- Anemia of Malignancy.- Heart Disease and Cancer.- Diet in Heart Disease and Cancer.- Carcinogens in Foods: Heterocyclic Amines and Cancer and Heart Disease.- Genetic Engineering of Foods to Reduce the Risk of Heart Disease and Cancer.- NIH Initiative.- New Directions in Dietary Studies in Cancer: The National Cancer Institute.- New Directions in Dietary Studies and Heart Disease; The National Heart, Lung and Blood Institute Sponsored Multicenter Study of Diet Effects on Lipoproteins and Thrombogenic Activity.- Abstracts of Poster Sessions.