Osler's Disease, A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions

by Kenneth Kee

Overview

This book describes Osler’s Disease, Diagnosis and Treatment and Related Diseases
Osler disease is an inherited blood vessel disease that produces bleeding from the mucous membranes of the nose, gastrointestinal tract, lungs or urinary tract.
Patients may also have abnormal blood vessels that bleed in the brain.
Osler Disease or Osler-Weber-Rendu syndrome (OWR) is also called hereditary hemorrhagic telangiectasia (HHT).
It is a genetic blood vessel disorder that often causes excessive bleeding.
It was first thought to be a bleeding disease but this disorder is caused by problems with the blood vessels themselves.
People with OWR may have missing capillaries in some of their blood vessels.
These abnormal blood vessels are termed arteriovenous malformations (AVM).
Because there is nothing to reduce the pressure of the blood before it moves into the veins, people with OWR often have strained veins that may ultimately rupture.
When large AVMs arise, hemorrhages can happen.
Hemorrhages in these locations can become life-threatening:
1. The brain
2. The lungs
3. The liver
4. The gastrointestinal tract
People with OWR also have abnormal blood vessels termed “telangiectasias” near the skin and mucosal surfaces.
These blood vessels are swollen or widened and are often seen as small red dots on the skin surface.
The disorder can be found throughout the world.
The syndrome involves about one in 5,000 people.
Many people with the disorder do not know they have it, so this number may really be higher.
There is no gender difference.
People with OWR have an abnormal gene that causes their blood vessels to form imperfectly.
OWR is an autosomal dominant genetic disease.
This means that only one parent requires having the abnormal gene to pass it on to their children.
OWR does not pass over a generation.
The signs and symptoms may differ greatly between family members.
If the patient has OWR, it is possible that the child could have a milder or more serious course.
In very rare cases, a child can be born with OWR even when none of the parents has the syndrome.
This occurs when one of the genes that cause OWR forms mutation in an egg or sperm cell.
Symptoms
Symptoms of OWR and their severity differ widely, even among family members.
A frequent sign of OWR is a large red birthmark, occasionally called a port wine stain.
A port-wine stain is produced by a collection of dilated blood vessels, and it may become darker in color as the person grows older.
Telangiectasias (small dilated blood vessels) are another frequent symptom of OWR.
They are often small red dots and are susceptible to bleeding.
The marks may be observed in young children or not until after puberty.
Telangiectasias can emerge on the:
1. Face
2. Lips
3. Tongue
4. Ears
5. Fingertips
6. Whites of the eyes
7. Gastrointestinal system
AVMs can happen anywhere inside the body.
The most frequent sites are:
1. The nose
2. The lungs
3. The gastrointestinal tract
4. The liver
5. The brain
6. The spine
The most frequent symptom of OWR is nosebleeds produced by telangiectasias in the nose.
In fact, this is often the first symptom of OWR.
Nosebleeds may occur daily or as rarely as twice per year.
When AVMs develop in the lungs, they can involve lung function.
A person with a lung AVM may have shortness of breath.
Diagnosis:
Blood test can examine for anemia, or iron deficiency in the blood.
CT scan can reveal internal AVMs, such as in the lungs, liver, and brain
Treatment:
Treatment is to stop bleeding and replace blood loss
Iron supplements
Transfusion
Estrogen
Aminocaproic acid
Electrocautery and argon beam ablation
Laser cautery
Embolization of blood vessel
Surgery

TABLE OF CONTENT
Introduction
Chapter 1 Osler’s Disease
Chapter 2 Causes
Chapter 3 Symptoms
Chapter 4 Diagnosis
Chapter 5 Treatment
Chapter 6 Prognosis
Chapter 7 Gastrointestinal Bleeding
Chapter 8 NoseBleeds
Epilogue

Product Details

BN ID:	2940163202867
Publisher:	Kenneth Kee
Publication date:	04/25/2019
Sold by:	Smashwords
Format:	eBook
File size:	204 KB

About the Author

Medical doctor since 1972. Started Kee Clinic in 1974 at 15 Holland Dr #03-102, relocated to 36 Holland Dr #01-10 in 2009. Did my M.Sc (Health Management ) in 1991 and Ph.D (Healthcare Administration) in 1993. Dr Kenneth Kee is still working as a family doctor at the age of 65. However he has reduced his consultation hours to 3 hours in the morning and 2 hours in the afternoon. He first started writing free blogs on medical conditions seen in the clinic in 2007 on http://kennethkee.blogspot.com. His purpose in writing these simple guides was for the health education of his patients which is also his dissertation for his Ph.D (Healthcare Administration). He then wrote an autobiolographical account of his journey as a medical student to family doctor on his other blog afamilydoctorstale.blogspot.com. This autobiolographical account “A Family Doctor’s Tale” was combined with his early “A Simple Guide to Medical Conditions” into a new Wordpress Blog “A Family Doctor’s Tale” on http://ken-med.com. From which many free articles from the blog was taken and put together into 550 amazon kindle books and some into Smashwords.com eBooks. He apologized for typos and spelling mistakes in his earlier books. He will endeavor to improve the writing in futures. Some people have complained that the simple guides are too simple. For their information they are made simple in order to educate the patients. The later books go into more details of medical conditions. The first chapter of all my ebooks is always taken from my blog A Simple Guide to Medical Conditions which was started in 2007 as a simple educational help to my patients on my first blog http://kennethkee.blogspot.com. The medical condition was described simply and direct to the point. Because the simple guide as taken from the blog was described as too simple, I have increased the other chapters to include more detailed description of the illness, symptoms, diagnosis and treatment. As a result there are the complaints by some readers of constant repetitions of the same contents but in detail and fairly up to date. He has published 550 eBooks on various subjects on health, 1 autobiography of his medical journey, another on the autobiography of a Cancer survivor, 2 children stories and one how to study for his nephew and grand-daughter. The purpose of these simple guides is to educate patient on health conditions and not meant as textbooks. He does not do any night duty since 2000 ever since Dr Tan had his second stroke. His clinic is now relocated to the Bouna Vista Community Centre. The 2 units of his original clinic are being demolished to make way for a new Shopping Mall. He is now doing some blogging and internet surfing (bulletin boards since the 1980's) starting with the Apple computer and going to PC. All the PC is upgraded by himself from XT to the present Pentium duo core. The present Intel i7 CPU is out of reach at the moment because the CPU is still expensive. He is also into DIY changing his own toilet cistern and other electric appliance. His hunger for knowledge has not abated and he is a lifelong learner. The children have all grown up and there are 2 grandchildren who are even more technically advanced than the grandfather where mobile phones are concerned. This book is taken from some of the many articles in his blog (now with 740 posts) A Family Doctor’s Tale. Dr Kee is the author of: "A Family Doctor's Tale" "Life Lessons Learned From The Study And Practice Of Medicine" "Case Notes From A Family Doctor"