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Plum and Posner's Diagnosis of Stupor and Coma
by Jerome B. Posner M.D., Clifford B. Saper M.D., Nicholas Schiff M.D., Fred Plum M.D.
Jerome B. Posner M.D.
Plum and Posner's Diagnosis of Stupor and Coma
by Jerome B. Posner M.D., Clifford B. Saper M.D., Nicholas Schiff M.D., Fred Plum M.D.
Jerome B. Posner M.D.
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Overview
Delirium, stupor and coma are common clinical states that confront clinicians in almost every medical specialty. With appropriate diagnosis and treatment, coma can often be treated successfully. Conversely, delay in diagnosis and treatment may be lethal. This monograph provides an update on the clinical approach that was laid out in the previous 3 editions. It describes an approach for the physician at the bedside to diagnose and treat alterations of consciousness, based on pathophysiologic principles. The book begins with a description of the physiology of consciousness and the pathophysiology of disorders of consciousness. It continues with a description of the approach to a patient with a disorder of consciousness, emphasizing the bedside examination, but including the use of modern imaging techniques. The important structural and metabolic causes of coma are reviewed in detail. It then describes the emergency treatment, both medical and surgical, of patients with specific disorders of consciousness and their prognosis. New chapters describe the approach to the diagnosis of brain death and the clinical physiology of the vegetative state and minimally conscious state, as well as the ethics of dealing with such patients and their families. The book is aimed at medical students and residents, in fields from internal medicine and pediatrics to emergency medicine, surgery, neurology, neurosurgery, and psychiatry, who are likely to encounter patients with disordered states of consciousness. It includes historical background and basic neurophysiology that is important for those in the clinical neurosciences, but also lays out a practical approach to the comatose patient that is an important part of the repertoire of all clinicians who provide emergency care for patients with disorders of consciousness.
Product Details
ISBN-13: | 9780199886531 |
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Publisher: | Oxford University Press |
Publication date: | 06/11/2007 |
Series: | Contemporary Neurology Series , #71 |
Sold by: | Barnes & Noble |
Format: | eBook |
File size: | 13 MB |
Note: | This product may take a few minutes to download. |
About the Author
Memorial Sloan Kettering Cancer Center
Beth Israel Deaconess Hospital and Harvard Medical School
Weill Cornell Medical College
Cornell University
Table of Contents
Pathophysiology of Signs and Symptoms of Coma 3
Altered States of Consciousness 3
Definitions 5
Consciousness
Acutely Altered States of Consciousness
Subacute or Chronic Alterations of Consciousness
Approach to the Diagnosis of the Comatose Patient 9
Physiology and Pathophysiology of Consciousness and Coma 11
The Ascending Arousal System
Behavioral State Switching
Relationship of Coma to Sleep
The Cerebral Hemispheres and Conscious Behavior
Structural Lesions That Cause Altered Consciousness in Humans
Examination of the Comatose Patient 38
Overview 38
History 39
General Physical Examination 40
Level of Consciousness 40
ABC: Airway, Breathing, Circulation 42
Circulation
Respiration
Pupillary Responses 54
Examine the Pupils and Their Responses
Pathophysiology of Pupillary Responses: Peripheral Anatomy of the Pupillomotor System
Pharmacology of the Peripheral Pupillomotor System
Localizing Value of Abnormal Pupillary Responses in Patients in Coma
Metabolic and Pharmacologic Causes of Abnormal Pupillary Response
Oculomotor Responses 60
Functional Anatomy of the Peripheral Oculomotor System
Functional Anatomy of the Central Oculomotor System
The Ocular Motor Examination
Interpretation of Abnormal Ocular Movements
MotorResponses 72
Motor Tone
Motor Reflexes
Motor Responses
False Localizing Signs in Patients with Metabolic Coma 75
Respiratory Responses
Pupillary Responses
Ocular Motor Responses
Motor Responses
Major Laboratory Diagnostic Aids 77
Blood and Urine Testing
Computed Tomography Imaging and Angiography
Magnetic Resonance Imaging and Angiography
Magnetic Resonance Spectroscopy
Neurosonography
Lumbar Puncture
Electroencephalography and Evoked Potentials
Structural Causes of Stupor and Coma 88
Compressive Lesions as a Cause of Coma 89
Compressive Lesions May Directly Distort the Arousal System 90
Compression at Different Levels of the Central Nervous System Presents in Distinct Ways
The Role of Increased Intracranial Pressure in Coma
The Role of Vascular Factors and Cerebral Edema in Mass Lesions
Herniation Syndromes: Intracranial Shifts in the Pathogenesis of Coma 95
Anatomy of the Intracranial Compartments
Patterns of Brain Shifts That Contribute to Coma
Clinical Findings in Uncal Herniation Syndrome
Clinical Findings in Central Herniation Syndrome
Clinical Findings in Dorsal Midbrain Syndrome
Safety of Lumbar Puncture in Comatose Patients
False Localizing Signs in the Diagnosis of Structural Coma
Destructive Lesions as a Cause of Coma 114
Diffuse, Bilateral Cortical Destruction 114
Destructive Disease of the Diencephalon 114
Destructive Lesions of the Brainstem 115
Specific Causes of Structural Coma 119
Introduction 120
Supratentorial Compressive Lesions 120
Epidural, Dural, and Subdural Masses 120
Epidural Hematoma
Subdural Hematoma
Epidural Abscess/Empyema
Dural and Subdural Tumors
Subarachnoid Lesions 129
Subarachnoid Hemorrhage
Subarachnoid Tumors
Subarachnoid Infection
Intracerebral Masses 135
Intracerebral Hemorrhage
Intracerebral Tumors
Brain Abscess and Granuloma
Infratentorial Compressive Lesions 142
Epidural and Dural Masses 143
Epidural Hematoma
Epidural Abscess
Dural and Epidural Tumors
Subdural Posterior Fossa Compressive Lesions 144
Subdural Empyema
Subdural Tumors
Subarachnoid Posterior Fossa Lesions 145
Intraparenchymal Posterior Fossa Mass Lesions 145
Cerebellar Hemorrhage
Cerebellar Infarction
Cerebellar Abscess
Cerebellar Tumor
Pontine Hemorrhage
Supratentorial Destructive Lesions Causing Coma 151
Vascular Causes of Supratentorial Destructive Lesions 152
Carotid Ischemic Lesions
Distal Basilar Occlusion
Venous Sinus Thrombosis
Vasculitis
Infections and Inflammatory Causes of Supratentorial Destructive Lesions 156
Viral Encephalitis
Acute Disseminated Encephalomyelitis
Concussion and Other Traumatic Brain Injuries 159
Mechanism of Brain Injury During Closed Head Trauma
Mechanism of Loss of Consciousness in Concussion
Delayed Encephalopathy After Head Injury
Infratentorial Destructive Lesions 162
Brainstem Vascular Destructive Disorders 163
Brainstem Hemorrhage
Basilar Migraine
Posterior Reversible Leukoencephalopathy Syndrome
Infratentorial Inflammatory Disorders 169
Infratentorial Tumors 170
Central Pontine Myelinolysis 171
Multifocal, Diffuse, and Metabolic Brain Diseases Causing Delirium, Stupor, or Coma 179
Clinical Signs of Metabolic Encephalopathy 181
Consciousness: Clinical Aspects 181
Tests of Mental Status
Pathogenesis of the Mental Changes
Respiration 187
Neurologic Respiratory Changes Accompanying Metabolic Encephalopathy
Acid-Base Changes Accompanying Hyperventilation During Metabolic Encephalopathy
Acid-Base Changes Accompanying Hypoventilation During Metabolic Encephalopathy
Pupils 192
Ocular Motility 193
Motor Activity 194
"Nonspecific" Motor Abnormalities
Motor Abnormalities Characteristic of Metabolic Coma
Differential Diagnosis 197
Distinction Between Metabolic and Psychogenic Unresponsiveness
Distinction Between Coma of Metabolic and Structural Origin
Aspects of Cerebral Metabolism Pertinent to Coma 198
Cerebral Blood Flow 198
Glucose Metabolism 202
Hyperglycemia
Hypoglycemia
Anesthesia 205
Mechanisms of Irreversible Anoxic-Ischemic Brain Damage 206
Global Ischemia
Focal Ischemia
Hypoxia
Evaluation of Neurotransmitter Changes in Metabolic Coma 208
Acetylcholine
Dopamine
Gamma-Aminobutyric
Acid
Serotonin
Histamine
Glutamate
Norepinephrine
Specific Causes of Metabolic Coma 210
Ischemia and Hypoxia 210
Acute, Diffuse (or Global) Hypoxia or Ischemia
Intermittent or Sustained Hypoxia
Sequelae of Hypoxia
Disorders of Glucose or Cofactor Availability 220
Hypoglycemia
Hyperglycemia
Cofactor Deficiency
Diseases of Organ Systems Other than Brain 224
Liver Disease
Renal Disease
Pulmonary Disease
Pancreatic Encephalopathy
Diabetes Mellitus
Adrenal Disorders
Thyroid Disorders
Pituitary Disorders
Cancer
Exogenous Intoxications 240
Sedative and Psychotropic Drugs
Intoxication With Other Common Medications
Ethanol Intoxication
Intoxication With Drugs of Abuse
Intoxication With Drugs Causing Metabolic Acidosis
Abnormalities of Ionic or Acid-Base Environment of the Central Nervous System 251
Hypo-osmolar States
Hyperosmolar States
Calcium
Other Electrolytes
Disorders of Systemic Acid-Base Balance
Disorders of Thermoregulation 259
Hypothermia
Hyperthermia
Infectious Disorders of the Central Nervous System: Bacterial 262
Acute Bacterial Leptomeningitis
Chronic Bacterial Meningitis
Infectious Disorders of the Central Nervous System: Viral 266
Overview of Viral Encephalitis
Acute Viral Encephalitis
Acute Toxic Encephalopathy During Viral Encephalitis
Parainfectious Encephalitis (Acute Disseminated Encephalomyelitis)
Cerebral Biopsy for Diagnosis of Encephalitis
Cerebral Vasculitis and Other Vasculopathies 273
Granulomatous Central Nervous System Angiitis
Systemic Lupus Erythematosus
Subacute Diencephalic Angioencephalopathy
Varicella-Zoster Vasculitis
Behcet's Syndrome
Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy
Miscellaneous Neuronal and Glial Disorders 276
Prion Diseases
Adrenoleukodystrophy (Schilder's Disease)
Marchiafava-Bignami Disease
Gliomatosis Cerebri
Progressive Multifocal Leukoencephalopathy
Epilepsy
Mixed Metabolic Encephalopathy
Acute Delirious States 282
Drug Withdrawal Delirium (Delirium Tremens)
Postoperative Delirium
Intensive Care Unit Delirium
Drug-Induced Delirium
Psychogenic Unresponsiveness 297
Conversion Reactions 299
Catatonia 302
Psychogenic Seizures 304
Cerebellar Cognitive Affective Syndrome 306
"Amytal Interview" 307
Approach to Management of the Unconscious Patient 309
A Clinical Regimen for Diagnosis and Management 309
Principles of Emergency Management 311
Ensure Oxygenation, Airway, and Ventilation
Maintain the Circulation
Measure the Glucose
Lower the Intracranial Pressure
Stop Seizures
Treat Infection
Restore Acid-Base Balance
Adjust Body Temperature
Administer Specific Antidotes
Control Agitation
Protect the Eyes
Examination of the Patient 317
Verbal Responses
Respiratory Pattern
Eye Opening
Pupillary Reactions
Spontaneous Eye Movement
Oculocephalic Responses
Caloric Vestibulo-Ocular Responses
Corneal Responses
Motor Responses
Tendon Reflexes
Skeletal Muscle Tone
Guides to Specific Management 320
Supratentorial Mass Lesions
Infratentorial Mass Lesions
Metabolic Encephalopathy
Psychogenic Unresponsiveness
A Final Word 327
Brain Death 331
Determination of Brain Death 331
Clinical Signs of Brain Death 333
Brainstem Function
Confirmatory Laboratory Tests and Diagnosis
Diagnosis of Brain Death in Profound Anesthesia or Coma of Undetermined Etiology
Pitfalls in the Diagnosis of Brain Death
Prognosis in Coma and Related Disorders of Consciousness, Mechanisms Underlying Outcomes, and Ethical Considerations 341
Introduction 342
Prognosis in Coma 343
Prognosis by Disease State 344
Traumatic Brain Injury
Nontraumatic Coma
Vascular Disease
Central Nervous System Infection
Acute Disseminated Encephalomyelitis
Hepatic Coma
Depressant Drug Poisoning
Vegetative State 357
Clinical, Imaging, and Electrodiagnostic Correlates of Prognosis in the Vegetative State
Minimally Conscious State 360
Late Recoveries From the Minimally Conscious State
Locked in State 363
Mechanisms Underlying Outcomes of Severe Brain Injury: Neuroimaging Studies and Conceptual Frameworks 364
Functional Imaging of Vegetative State and Minimally Conscious State 365
Atypical Behavioral Features in the Persistent Vegetative State
Neuroimaging of Isolated Cortical Responses in Persistent Vegetative State Patients
Potential Mechanisms Underlying Residual Functional Capacity in Severely Disabled Patients 372
Variations of Structural Substrates Underlying Severe Disability
The Potential Role of the Metabolic "Baseline" in Recovery of Cognitive Function
The Potential Role of Regionally Selective Injuries Producing Widespread Effects on Brain Function
Ethics of Clinical Decision Making and Communication with Surrogates (J.J. Fins) 376
Surrogate Decision Making, Perceptions, and Needs
Professional Obligations and Diagnostic Discernment
Time-Delimited Prognostication and Evolving Brain States: Framing the Conversation
Family Dynamics and Philosophic Considerations
Index 387
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