Polymorphism in Pharmaceutical Solids

by Harry G. Brittain (Editor)

Overview

Using clear and practical examples, Polymorphism of Pharmaceutical Solids, Second Edition presents a comprehensive examination of polymorphic behavior in pharmaceutical development that is ideal for pharmaceutical development scientists and graduate students in pharmaceutical science. This edition focuses on pharmaceutical aspects of polymorphism a

Product Details

ISBN-13:	9781040172438
Publisher:	CRC Press
Publication date:	11/12/2018
Series:	Drugs and the Pharmaceutical Sciences
Sold by:	Barnes & Noble
Format:	eBook
Pages:	656
File size:	21 MB
Note:	This product may take a few minutes to download.

Table of Contents

1. Thermodynamic and Theoretical Issues. 1.1. Theory and Origin of Polymorphism. 1.2. Application of the Phase Rule. 1.3. Computational Methodologies. 2. Preparative Methods for Polymorphs and Solvatomorphs. 2.1. Classical Methods of Preparation. 2.2. High-Throughput Screening Methods. 3. Structural Properties of Polymorphs and Solvatomorphs. 3.1. Polymorphic Systems. 3.2. Solvatomorphic Systems. 3.3. Pharmaceutical Cocrystals. 4. Characterization Methods for Polymorphs and Solvatomorphs. 4.1. Thermal and Crystallographic. 4.2. Vibrational Spectroscopy. 4.3. Solid-State NMR. 4.4. Solubility and Dissolution Rate. 5. Interconversion of Polymorphs and Solvatomorphs. 5.1. Thermally-Induced and Solution-Mediated Phase Transformations. 5.2. Effects of Secondary Processing. 5.3. Structural Aspects of Molecular Dissymmetry. 5.4. Amorphous Solids.

Editorial Reviews

...an excellent reference source for any researcher working in this field...a theoretical and practical guide.

Journal of Controlled Release

Summarizing the major issues pertaining to the pharmaceutical aspects of polymorphism, as well as the effects of solvate formation, this volume is divided into five main sections. The first two sections provide definitions of the phenomenon and address crystallographic considerations defining different polymorphic and solvate species. Part three covers practical procedures including those used to generate all possible polymorphs and hydrate species that might exist for a given substance and the principal analysis methods used. The consequences associated with the existence of polymorphic forms are addressed in the fourth section, while the last contains two chapters less directly related to polymorphism: structural variations that can arise from the existence of molecular dissymmetry and the impact of polymorphism on the quality of amorphous materials produced by lyophilization. Of likely interest to industrial and product development pharmacists, pharmaceutical scientists, chemists, and graduate level students in related disciplines. Annotation c. by Book News, Inc., Portland, Or.

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