Process Development: Fine Chemicals from Grams to Kilograms

by Stan Lee, Graham Robinson

Overview

Process development bridges the gap between the laboratory synthesis of an organic compound and its industrial manufacture on a large scale. This concise and readable text uses real examples and case histories from ICI/Zeneca Pharmaceuticals to show the problems which may be encountered in scaling up chemical synthesis, and the ways these problems may be overcome. It shows how it is possible to synthesize multi-kilogram quantities of a new organic compound which has been made in the laboratory only in the milligram scale. A wide range of aliphatic, aromatic, and heterocyclic compounds is covered. This book will be invaluable both to the research chemist involved in the development phase of novel compounds, and the advanced undergraduate interested in the fine chemicals industry.

Product Details

ISBN-13:	9780198558248
Publisher:	Oxford University Press
Publication date:	08/24/1995
Series:	Oxford Chemistry Primers , #30
Edition description:	1st Edition
Pages:	98
Product dimensions:	9.70(w) x 7.42(h) x 0.22(d)

About the Author

Zeneca Pharmaceuticals, Macclesfield, Cheshire

Zeneca Pharmaceuticals, Macclesfield, Cheshire

Table of Contents

Introduction1. Scale up issues2. Environmental and regulatory issyes3. Fun with cephalosporins4. Thromboxane antagonists5. Homochiral thrombozane antagonists6. H2 blockers7. Development of a manufacturing route for cloprostenol sodium8. Synthesis of a potentially anti-obesity agent9. Reagents for large scale operation