Quantification of Brain Function Using PET

by Ralph Myers (Editor), Vin Cunningham (Editor), Dale Bailey (Editor)

Overview

Functional imaging of the brain is one of the most rapidly advancing areas of neuroscience and Positron Emission Tomography (PET) plays a major role in this progress. This book provides a comprehensive overview of the current status of PET and state-of-the-art neuroimaging. It is comprised of summaries of the presentations by experts in the field. Topics covered include radiotracer selection, advances in instrumentation, image reconstruction and data analysis, and statistical mapping of brain activity. This book focuses on the accuracy of the functional image and the strategies for addressing clinical, scientific, and diagnostic questions.Covers the PET imaging process from tracer selection to analysis and interpretationContains 79 concise reports with abundant illustrationsThe definitive state-of-the-art book for functional neuroscience with PET

Product Details

ISBN-13:	9780080540108
Publisher:	Elsevier Science & Technology Books
Publication date:	07/17/1996
Sold by:	Barnes & Noble
Format:	eBook
Pages:	443
File size:	20 MB
Note:	This product may take a few minutes to download.

Table of Contents

Tracer Selection: M.R. Kilbourn, In Vivo-In Vitro Correlations: An Example from Vesicular Monoamine Transporters. W.D. Brown, O.T. DeJesus, S.E. Shelton, H. Uno, D. Houser, R.J. Nickles, S.J. Swerdloff, A. Roberts, E. Baker, and J.E. Holden, The Noncatechol Tracer 6-flouro-m-tyrosine: Extrastriatal Distribution of Dopaminergic Function. R. Myers, S.P. Hume, S. Ashworth, A.A. Lammertsma, P.M. Bloomfield, S. Rajeswaran, and T. Jones, Quantification of Dopamine Receptors and Transporter in Rat Striatum Using a Small Animal PET Scanner. W.-D. Heiss, K. Wienhard, R. Graf, J. Lottgen, U. Pietrzyk, and R. Wagner, Applicability of Experimental PET in Animal Models for the Interpretation of Incidental Findings in Human Stroke. A. Malizia, G. Forse, R.N. Gunn, A. Haida, L. Schnorr, S. Rajeswaran, K. Poole, D. Nutt, and T. Jones, The MOC Counter--A Pharmacological Tool for the in Vivo Measurement of Ligand Occupancy Indices in the Human Brain. A. Biegon, C. Mathis, and W. Jagust, Autoradiography As a Tool for PET/SPECT Tracer Selection and Assessment. S. Osman, J.A. McCarron, S.P. Hume, S. Ashworth, V.W. Pike, S.K. Luthra, A.A. Lammertsma, C. Bench, P. Grasby, I.A. Cliffe, and A.Fletcher, Radioactive Metabolites of the 5-HT1A Receptor Radioligand, [O-methyl-11C]WAY-100635, in Humans. D.F. Smith, R. Glaser, A. Gee, and A. Gjedde, 11C-Nefopam as a Potential PET Tracer of Serotonin Reuptake Sites: Initial Findings in Living Pig Brain. A.D. Gee, N. Gillings, D. Smith, O. Inoue, K. Kobayashi, and A. Gjedde, The Effect of Amine pKa on the Transport and Binding of Amphetamine Analogues in Pig Brain: An in Vivo Comparison of B, B-Difluoro[N-methyl11C]methamphetamine Using PET. M.R. Kilbourn, Tacer Selection Summary. Data Acquisition: S.R. Meikle, S. Eberl, B.F. Hutton, P.K. Hooper, and M.J. Fulham, Application of Simultaneous Emission and Transmission Scanningto Quantitative Cerebral PET. H. Iida, S. Miura, I. Kanno, T. Ogawa, and K. Uemura, A New PET Camera for Noninvasive Quantitation of Physiological Functional Parametric Images: HEADTOME-V-DUAL. S. Ashworth, A. Ranicar, P.M. Bloomfield, T. Jones,and A.A. Lammertsma, Development of an On-Line Blood Detector System for PET Studies in Small Animals. M. Itoh, H. Watabe, M. Miyake, S. Hagisawa, T. Fujiwara, R. Iwata, T. Ido, and T. Nakamura, Noninvasive Determination of Arterial Input of 15O Tracers Using a Dual Cutaneous B-Detector Set above the Radial Artery. M. Vafaee, K. Murase, A. Gjedde, and E. Meyer, Dispersion Correction for Automatic Sampling of O-15 Labeled H2O and Red Blood Cells. D.W. Townsend, J.C. Price, B.J. Lopresti, M.A. Mintun, P.E. Kinahan, F. Jadali, S. Sashin, N.R. Simpson, and C. A. Mathis, Scatter Correction for Brain Receptor Quantitation in 3D PET. J.S. Rakshi, D.L. Bailey, P.K. Morrish, and D.J. Brooks, Implementation of 3D Acquisition,Reconstruction and Analysis of Dynamic 18F Fluorodopa Studies. R. Trebossen, B. Bendriem, A. Fontaine, V. Frouin, and P. Remy, Quantitation of the [18F]Fluorodopa Uptake in the Human Striata in 3D PET with the ETM Scatter Correction. S. Holm, I. Law, and O.B. Paulson, 3D PET Activation Studies with H215O Bolus Injection: Count Rate Performance and Dose Optimization. N. Sadato, R.E. Carson, M.E. Daube-Witherspoon, G. Campbell, M. Hallett, and P. Herscovitch, Optimization of Noninvasive Activation Studies with O-15-Water and 3D PET. L. Eriksson,Data Acquisition Summary. Data Processing: J.T. Yap, C.-M. Kao, M. Cooper, C.-T. Chen, and M. Wernick, Sinogram Recovery of Dynamic PET Using Principal Component Analysis and Projections onto Convex Sets. B.A. Ardekani, M. Braun, B.F. Hutton, and I. Kanno, Minimum Cross Entropy Reconstruction of PET Images Using Prior Anatomical Information Obtained from MR. B. Lipinski, H. Herzog, E.R. Kops, W. Oberschelp, H.W. Muller-Gartner, MR Guided PET Reconstruction and Problems with Anatomical Misinformation. A.C. Evans, D.L. Collins, and C.J.

Editorial Reviews

This book is based on the July 1995 Symposium held in Oxford on the quantification of brain function with PET. Its purpose is to bring together in a timely fashion recent advances in this field. The emphasis of the symposium was on achieving maximum accuracy and formulating the proper strategies for addressing research and diagnostic questions. For this purpose, a systematic approach was chosen to address the multiple steps required to answer the diagnostic question in an appropriate manner: selection of tracers, data acquisition, processing, kinetic analysis, parametric imaging, and statistical analysis. This comprehensive approach has the potential to interest a variety of groups and disciplines working with PET or using the results of PET: radiopharmacists, physicists, physicians, and postgraduate students involved in research or in clinical PET work. The book is divided into five parts: tracer selection, data acquisition, data processing, kinetic analysis, and statistical analysis. Good quality illustrations are provided throughout, some in color. A most useful feature is the presence of an extensive summary at the end of each part, written by a well-known expert in the field. The book represents an excellent source of up-to-date information in this field. Although it cannot escape the intrinsic limitations of any volume based on symposia (uneven coverage of the subject), the authors have gone to great lengths to minimize this weakness. This is accomplished by a good set of references given for every single chapter and by the summary at the end of each of the five parts. These summaries represent not only an excellent overview of the main topics addressed, but four out of thefive authors have also interspersed their own most interesting views concerning the present status and the projected future developments. This book is a worthwhile addition, for a reasonable price, to be considered by libraries and individuals alike.

Dan G. Pavel

A complete overview surveying the current functions of positron emission tomography (PET) in neuroscience and investigations into brain functioning. The 83 discussions, written by researchers and practitioners in the field, cover topics in radiotracer selection, advances in instrumentation, image reconstruction and data analysis, and statistical mapping of brain activity. Each contribution focuses on functional image accuracy and strategies for answering clinical, scientific, and diagnostic questions using PET. Includes a wealth of diagrams and photographs, making the volume almost atlas-like in its quality. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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