Table of Contents
1. From Neanderthal to Nanobiotech: from plant potions to pharming with plant factories
Christophe Sourrouille, Brian Marshall, David Liénard and Loïc Faye
2. Cowpea Mosaic Virus-based systems for the expression of antigens and antibodies in plants.
Frank Sainsbury, Li Liu and George P. Lomonossoff
3. Transient expression of antibodies in plants using syringe agroinfiltration
Marc-André D’Aoust, Pierre-Olivier Lavoie, Julie Belles-Isles, Nicole Bechtold, Michèle Martel and Louis-P. Vézina
4. Rapid system for evaluating bioproduction capacity of complex pharmaceutical proteins in plants
Giuliana Medrano, Michael J. Reidy, Jianyun Liu, Jorge Ayala, Maureen C. Dolan and Carole L. Cramer
5. Production and localization of recombinant pharmaceuticals in transgenic seeds
Thomas Rademacher, Elsa Arcalis and Eva Stoger
6. Production of antibody fragments in Arabidopsis seeds
Bart Van Droogenbroeck, Kirsten De Wilde and Ann Depicker
7. Production of plantibodies in Nicotiana plants
Marta Ayala, Jorge Gavilondo, Meilyn Rodríguez, Alejandro Fuentes, Gil Enríquez, Lincidio Pérez, José Cremata, and Merardo Pujol.
8. Physcomitrella patens: a non-vascular plant for recombinant protein production
David Lienard and Fabien Nogue
9. Production of recombinant proteins in suspension-cultured plant cells
Carole Plasson, Rémy Michel, David Lienard, Claude Saint-Jore-Dupas, Christophe Sourrouille, Ghislaine Grenier de March and Véronique Gomord
10. Chloroplast-derived vaccine antigens and biopharmaceuticals: Prools for expression, purification or oral delivery and functional evaluation
N. Dolendro Singh, Yi Ding and Henry Daniell
11. Protein body induction: a new tool to produce and recover recombinant proteins in plants
Margarita Torrent, Imma Llop and M.Dolors Ludevid
12. A case study for plant-made pharmaceuticals comparing different plant expression and production systems
Guy Vancanneyt, Manuel Dubald, Werner Schröder, Jörg Peters and Johan Botterman
13. Glycosylation of antibody therapeutics: optimisation for purpose
Roy Jefferis
14. N-Glycosylation of Plant Recombinant Pharmaceuticals
Muriel Bardor, Gleysin Cabrera, Johannes Stadlmann, Patrice Lerouge, José A. Cremata, Véronique Gomord and Anne-Catherine Fitchette
15. Companion protease inhibitors to protect recombinant proteins in transgenic plant extracts
Meriem Benchabane, Daniel Rivard, Cécile Girard, and Dominique Michaud
16. Strategies for improving vaccine antigens expression in transgenic plants. Fusion to carrier sequences
Jose M. Escribano and Daniel M. Perez-Filgueira
17. Immunomodulation of plant function by in vitro selected single-chain Fv intrabodies
Manfred Gahrtz and Udo Conrad
18. On-chip detection of low-molecular-weight recombinant proteins in plant crude extracts by SELDI-TOF MS
Amine M. Badri, Karine Coenen, Louis-Philippe Vaillancourt, Charles Goulet, and Dominique Michaud
19. Assessing the Risk of Undesirable Immunogenicity/Allergenicity of Plant-Derived Therapeutic Proteins
Paul D. Chamberlain
20. Biosafety, Risk Assessment and Regulation of Plant-made Pharmaceuticals
Penelope A.C.Sparrow and Richard M.Twyman
