Separation Processes in Biotechnology

by Juan A. Asenjo

Overview

Edited to avoid duplication and favor comprehensiveness, 20 contributors detail the recovery, separation, and purification operations of bioprocess technology. Individual chapters in this classic yet still highly relevant work emphasize concepts that are becoming more and more important when applied to the large scale versions of techniques that are considered well established. Aside from fully discussing processes, Separation Processes in Biotechnology includes sections on concentration separation and operation, purification operations, and product release and recovery. It also discusses plant operation and equipment and delves into economic considerations

Product Details

ISBN-13:	9781000147537
Publisher:	CRC Press
Publication date:	08/26/2020
Sold by:	Barnes & Noble
Format:	eBook
Pages:	824
File size:	17 MB
Note:	This product may take a few minutes to download.

About the Author

Juan A. Asenjo is a Reader in Biochemical Engineering at the University of Reading, England. He was previously Associate Professor of Chemical and Biochemical Engineering at Columbia University, New York, New York. The author or coauthor of numerous publications, he is a member of the American Chemical Society, American Institute of Chemical Engineers, New York Academy of Sciences, and the Permanent Committee of Biotechnology of the Interciencia Association of the American Association for the Advancement of Science. Dr. Asenjo received the Ing. Civ. Quim degree (1974) in chemical engineering from the University of Chile, M.Sc. degree (1975) in food engineering from the University of Leeds, England, and Ph.D. degree (1978) in biochemical engineering from the University College, London, England.

Table of Contents

Series Introduction -- Foreword (Alan S. Michaels) -- Preface -- I Separation Processes -- 1 Selection of Operations in Separation Processes /Juan A. Asenio -- 2 Chemical, Physical, and Biochemical Concepts in Isolation and Purification of Proteins /Milton T. W. Hearn and Birger Anspach -- II Product Release and Recovery -- 3 Protein Secretion Systems in Microbial and Mammalian Cells /Donald T. Moir and Jen-I Mao -- 4 Cell Disruption by Homogenizer /Cady R. Engler -- 5 Bead Mill Disruption /Horst Schutte and Maria-Regina Kula -- 6 Enzymatic Cell Lysis for Product Release /Juan A. Asen;o and Barbara A. Andrews -- 7 Chemical Permeabilization of Cells for Intracellular Product Release /Thomas J. Naglak, David J. Hettwer, and Henry Y. Wang -- III Concentration and Separation Operations -- 8 Membrane Systems /A. G. Fane and J. M. Radovich -- 9 Ion -Exchange Processes /Charles D. Shuey -- 10 Aqueous Two-Phase Separations /Per-Jke Albertsson, Cote Johansson, and Folke T jerneld -- 11 Precipitation /Charles E. Glatz -- IV Purification Operations -- 12 Ion Exchange in Purification /Nien-Hwa Linda Wang -- 13 Process Affinity Chromatography /Yannis D. Clonis -- 14 Reversed-Phase and Hydrophobic Interaction Chromatography of Peptides and Proteins /Ziad El Rossi, Ann L. Lee, and Csaba Horvath -- 15 Analysis of Effluent Profiles in Large-Scale Liquid Chromatography /J. Hong -- 16 Electrically Driven Separation Processes: Analytical and Preparative Methods /Cornelius F. Ivory -- V Design of Separation Processes -- 17 Synthesis of Downstream Processes /George J. Prokopakis and Juan A. Asenjo -- 18 Automation in Protein Purification: The Use of Expert Systems for Control of Process Chromatography /Andrew C. Kenney -- 19 Downstream Processing Plant and Equipment /M. P. Brocklebank -- 20 Downstream Process Economics /Rajiv Datar and Carl-Gustaf Rosen -- Index.

Editorial Reviews

Edited to avoid duplication and favor comprehensiveness, 20 contributions detail the recovery, separation, and purification operations of bioprocess technology. Individual chapters emphasize concepts that are, and will be, important in the large scale versions of techniques that have been well established at the laboratory level. These concepts lie in the interface of basic physical biochemistry and biomedical engineering, and this collection, useful as both a text and a reference, will also stimulate creative interaction between biological scientists and chemical engineers. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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