Stem Cell Therapy for Autoimmune Disease

Stem Cell Therapy for Autoimmune Disease

by Richard K. Burt, A. M. Marmont

Hardcover

$140.00

Product Details

ISBN-13: 9781587060311
Publisher: Taylor & Francis
Publication date: 05/10/2004
Pages: 512
Product dimensions: 11.00(w) x 8.70(h) x 1.50(d)

Table of Contents

1.When is a Stem Cell Really a Stem Cell?1
2.Embryonic Stem Cells: Unique Potential to Treat Autoimmune Diseases5
3.Neural Stem Cells and Oligodendrocyte Progenitors in the Central Nervous System11
4.Turning Blood into Liver18
5.Adipose Tissue-Derived Adult Stem Cells: Potential for Cell Therapy24
6.Hematopoietic Stem Cell Biology: Relevance to Autoimmunity31
7.Properties and Therapeutic Potentials of Adult Stem Cells from Bone Marrow Stroma (MSCs)35
8.Regeneration of Cardiomyocytes from Bone Marrow Stem Cells and Application to Cell Transplantation Therapy39
9.Clinical Trials of Hematopoietic Stem Cells for Cardiac and Peripheral Vascular Diseases49
10.The Stem Cell Continuum: A Plastic Plasticity55
11.Adult Stem Cell Plasticity59
12.Collection and Expansion of Stem Cells73
13.The Extracellular Matrix as a Substrate for Stem Cell Growth and Development and Tissue Repair87
14.Gene Transfer into Human Hematopoietic Stem Cells: Problems and Perspectives92
15.The Etiopathogenesis of Autoimmunity106
16.Overview of Immune Tolerance Strategies113
17.Death Receptor-Mediated Apoptosis and Lymphocyte Homeostasis119
18.Shifting Paradigms in Peripheral Tolerance132
19.Dendritic Cells Control the Balance between Tolerance and Autoimmunity139
20.CD4[superscript +] T Regulatory Cells and Modulation of Undesired Immune Responses148
21.Major Histocompatibility Complex and Autoimmune Disease155
22.Analyzing Complex Polygenic Traits: The Role of Non-HLA Genes in the Susceptibility to Autoimmune Disorders164
23.Drug-Induced Autoimmunity173
24.Evidence for a Role of Infections in the Activation of Autoreactive T Cells and the Pathogenesis of Autoimmunity182
25.Molecular Analysis of Immunity194
26.Immune Reconstitution after Hematopoietic Stem Cell Transplantation206
27.Historical Perspective and Rationale of HSCT for Autoimmune Diseases223
28.High-Dose Immune Suppression without Hematopoietic Stem Cells for Autoimmune Diseases232
29.Autologous Stem Cell Transplantation in Animal Models of Autoimmune Diseases237
30.Allogeneic Hemopoietic Stem Cell Transplantation in Animal Models of Autoimmune Disease245
31.Mobilization and Conditioning Regimens in Stem Cell Transplant for Autoimmune Diseases253
32.Infection in the Hematopoeitic Stem Cell Transplant Recipient with Autoimmune Disease262
33.Immunological Aspects of Multiple Sclerosis with Emphasis on the Potential Use of Autologous Hemopoietic Stem Cell Transplantation277
34.Axonal Injury and Disease Progression in Multiple Sclerosis284
35.Monitoring Disease Activity in Multiple Sclerosis290
36.Intense Immunosuppression Followed by Autologous Stem Cell Transplantation in Severe Multiple Sclerosis Cases: MRI and Clinical Data
37.Hematopoietic Stem Cell Transplantation for Multiple Sclerosis: Finding Equipoise309
38.Molecular and Cellular Pathogenesis of Systemic Lupus Erythematosus320
39.Definition, Classification, Activity and Damage Indices in Systemic Lupus Erythematosus328
40.Lupus Nephritis339
41.Hematopoietic Stem Cell Transplantation for Systemic Lupus Erythematosus347
42.Treatment of Rheumatoid Arthritis358
43.Haemopoietic Stem Cell Transplantation for Rheumatoid Arthritis--World Experience and Future Trials367
44.Autologous Stem Cell Transplantation for Refractory Juvenile Idiopathic Arthritis (JIA)378
45.Immunology of Scleroderma388
46.Hematopoietic Stem Cell Transplantation for Systemic Sclerosis398
47.High-Dose Immunosuppressive Chemotherapy with Autologous Stem Cell Support for Chronic Autoimmune Thrombocytopenia404
48.High-Dose Chemotherapy with Haematopoietic Stem Cell Transplantation in Primary Systemic Vasculitis, Behcet's Disease and Sjogren's Syndrome411
49.Hematopoietic Stem Cell Transplantation in the Treatment of Chronic Inflammatory Demyelinating Polyradiculoneuropathy419
50.Hematopoietic Stem Cell Therapy for Patients with Refractory Myasthenia Gravis429
51.Hematopoietic Stem Cell Transplantation in Patients with Autoimmune Bullous Skin Disorders434
52.Idiopathic Inflammatory Myositis437
53.Hematopoietic Stem Cell Transplantation as Treatment for Type 1 Diabetes442
54.Autologous Hematopoietic Stem Cell Transplantation for Crohn's Disease448
55.Bronchial Asthma and Idiopathic Pulmonary Fibrosis as Potential Targets for Hematopoietic Stem Cell Transplantation457
56.Autologous Stem Cell Transplantation in Relapsing Polychondritis468
57.Allogeneic Hematopoietic Stem Cell Transplantation for Autoimmune Diseases474
Index481

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