Target Organ Toxicity, Volume I

by Gerald M. Cohen

Overview

This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.

Product Details

ISBN-13:	9781000722369
Publisher:	CRC Press
Publication date:	01/29/2020
Sold by:	Barnes & Noble
Format:	eBook
Pages:	242
File size:	3 MB

About the Author

Gerald M. Cohen Ph.D. is Head of the Toxicology Unit, Department of Pharmacology, The School of Pharmacy, University of London. Dr. Cohen graduated in 1966 from Leeds University, Leeds, U.K., with a B.Sc. Honours degree in pharmacy and obtained his Ph.D. degree in pharmacology in 1973 from the University of Minnesota, Minneapolis. He is a member of the British Toxicology Society, British Association for Cancer Research, American Association for Cancer Research, Society for Free Radical Research and the Biochemical Society. Dr. Cohen has presented many invited lectures at both International and National Meetings. He has published more than 60 research papers. His current major research interests include mechanisms of selective toxicity and target organ toxicity.

Table of Contents

Chapter 1 Basic Principles of Target Organ Toxicity, Chapter 2 Role of Pharmacokinetics in Rationalizing Tissue Distribution, Chapter 3 The Role of Metabolic Activation in Target Organ Toxicity, Chapter 4 Role of Excretion, Chapter 5 Species Variation in Target Organ Toxicity, Chapter 6 The Importance of Tissue-Specific Biochemistry in the Determination of Target Organ Toxicity, Chapter 7 Role of Key Defense Systems in Target Organ Toxicity, Chapter 8 The Liver as a Target Organ for Toxicity, Chapter 9 The Nervous System as a Target Organ for Toxicity, Index