The Adhesion Molecule FactsBook

by Clare Isacke (Editor), Michael A. Horton (Editor)

Overview

This updated and expanded Second Edition of The Adhesion Molecule FactsBook has nearly double the number of entries of the First Edition, and provides a compendium of the major cell surface adhesion molecules. The introductory chapters detail the organization of the data in the entries section, provide a background to the main adhesion molecule families, and inform the reader how to access information on adhesion molecules on the Internet. The entries have been designed to allow the reader to quickly establish the main structure and functional features of each molecule and where to find information. - Alternative nomenclature - Tissue distribution and regulation of expression - Ligands - Gene organization and chromosomal location - Protein structure and molecular weights - Amino acid sequence of the most commonly studied organisms - PIR, SWISSPROT, and EMBL/GenBank accession numbers - Biological function - Key references

Product Details

ISBN-13:	9780080525976
Publisher:	Elsevier Science & Technology Books
Publication date:	08/24/2000
Series:	Factsbook
Sold by:	Barnes & Noble
Format:	eBook
Pages:	336
File size:	17 MB
Note:	This product may take a few minutes to download.

About the Author

Clare Isacke received her undergraduate degree in biochemistry in Oxford, her D.Phil. in Oxford working with John Heath and Chris Graham on growth control and differentiation of embryonal carcinoma cells. She worked as a postdoctoral fellow at the Salk Institute in La Jolla, California, with Tony Hunter and Ian Trowbridge on cell adhesion and tyrosine kinase receptors. She has been at Imperial College now for 10 years during which time the lab has been focussing on cell adhesion receptor. Isacke did a three-year stint in the Biochemistry Department at Imperial College setting up her own lab within the Colin Hopkins empire and then moved over to the Biology Department taking up a University-funded post.
Michael Horton trained in Biochemistry, Medicine and Haematology at St. Bartholomew's Hospital Medical College, London before research training in Immunology at University College, London. He has held senior appointments at St. Bartholomew's Hospital and with the Imperial Cancer Research Fund. He is currently Professor of Medicine and Head of the Bone and Mineral Center, University College, London. His research interests focus on the cell and molecular biology of bone, with a special interest in cell adhesion receptors, and in the development of novel therapeutics for bone disease.

Table of Contents

Preface		vii
Abbreviations		viii
Section I THE INTRODUCTORY CHAPTERS
Introduction		2	(5)
Adhesion Molecule Families		7	(26)
Accessing Information on the World Wide Web		33	(276)
Section II CELL ADHESION MOLECULES
Cadherins
E-Cadherin		43	(3)
N-Cadherin		46	(3)
P-Cadherin		49	(2)
R-Cadherin		51	(2)
VE-Cadherin		53	(2)
K-Cadherin		55	(2)
Cadherin-8		57	(2)
OB-Cadherin		59	(2)
Br-Cadherin		61	(2)
H-Cadherin		63	(2)
Cadherin-14		65	(2)
M-Cadherin		67	(2)
Ksp-Cadherin		69	(2)
LI-Cadherin		71	(2)
Desmocollin 1		73	(3)
Desmocollin 2		76	(2)
Desmocollin 3		78	(2)
Desmoglein 1		80	(3)
Desmoglein 2		83	(2)
Desmoglein 3		85	(4)
Immunoglobulin superfamily
ALCAM		89	(2)
CD22α and β		91	(3)
CD31		94	(3)
CD33		97	(2)
CD96		99	(2)
CD147		101	(2)
CEACAM family		103	(5)
Contactin-1		108	(3)
ICAM-1		111	(3)
ICAM-2		114	(2)
ICAM-3		116	(2)
ICAM-4		118	(2)
ICAM-5		120	(2)
JAM		122	(2)
L1		124	(3)
MAdCAM-1		127	(2)
MAG		129	(2)
MUC18		131	(2)
NCAM		133	(3)
P(0)		136	(2)
Sialoadhesin		138	(3)
TAG-1		141	(2)
VCAM-1		143	(6)
Integrins
Integrin αL		149	(3)
Integrin αM		152	(3)
Integrin αX		155	(2)
Integrin αD		157	(2)
Integrin α1		159	(2)
Integrin α2		161	(3)
Integrin α3		164	(3)
Integrin α4		167	(3)
Integrin α5		170	(3)
Integrin α6		173	(3)
Integrin α7		176	(2)
Integrin α8		178	(2)
Integrin α9		180	(2)
Integrin α10		182	(2)
Integrin αIIb		184	(3)
Integrin αV		187	(3)
Integrin αE		190	(2)
Integrin β1		192	(3)
Integrin β2		195	(3)
Integrin β3		198	(3)
Integrin β4		201	(3)
Integrin β5		204	(2)
Integrin β6		206	(2)
Integrin β7		208	(2)
Integrin β8		210	(5)
Selectins
E-Selectin		215	(3)
L-Selectin		218	(2)
P-Selectin		220	(5)
Syndecans
Syndecan-1		225	(2)
Syndecan-2		227	(2)
Syndecan-3		229	(2)
Syndecan-4		231	(4)
Other Molecules
AMOG		235	(2)
CD6		237	(2)
CD23		239	(2)
CD34		241	(3)
CD36		244	(3)
CD39		247	(2)
CD42a		249	(2)
CD42b		251	(3)
CD42c		254	(2)
CD42d		256	(2)
CD43		258	(3)
CD44		261	(3)
CD57		264	(2)
CD98		266	(2)
CD164		268	(3)
Claudin-1		271	(2)
Claudin-3		273	(2)
Claudin-4		275	(2)
Claudin-5		277	(2)
Claudins-other		279	(1)
Collagen type XIII (α1 chain)		280	(2)
Collagen type XVII (α1 chain)		282	(3)
Dystroglycan		285	(3)
E48		288	(2)
ESL-1		290	(2)
Galectin 3		292	(2)
GlyCAM-1		294	(2)
HSA		296	(2)
LYVE-1		298	(2)
Occludin		300	(2)
PCLP1		302	(2)
PSGL-1		304	(3)
VAP-1		307	(2)
Index		309

Editorial Reviews

Praise for the First Edition
"This book constitutes a handy resource to be included in your library among the more-specialized books of adhesion receptors and adhesion molecules." --IMMUNOLOGY TODAY

From the Publisher