The Oxford Handbook of Neuronal Ion Channels

by Arin Bhattacharjee (Editor)

Overview

Neurons are excitable cells. They use ions and electrical signaling to talk to each to other and when they talk to each other, neurons control behavior. The Oxford Handbook of Neuronal Ion Channels is an accessible reference describing the nature and properties of ion channels in neurons. The book explains how ion channels open and close, how they can be selective for specific ions, and how they give rise to action potentials. Included are in-depth chapters discussing specific classes of ion channels: potassium channels, sodium channels, neurotransmitter-gated ion channels and other specialized channels. Throughout the handbook, important insight is provided on the contribution ion channels make to neuronal excitability and to synaptic transmission. The handbook goes further to discuss channelopathies, a group of human diseases such as epilepsy, pain and migraines that can be caused by ion channel dysfunction. For neuroscientists, biophysicists and neuropharmacologists, this handbook is a valuable reference of ion channel biology and function.

Product Details

ISBN-13:	9780190669195
Publisher:	Oxford University Press
Publication date:	02/10/2023
Series:	OXFORD HANDBOOKS SERIES
Sold by:	Barnes & Noble
Format:	eBook
Pages:	512
File size:	28 MB
Note:	This product may take a few minutes to download.

About the Author

Arin Bhattacharjee obtained his Bachelor's degree and Pharmacology Certificate from the University of Alberta in 1992. He completed doctoral training from the University of South Alabama with Dr. Ming Li in 1999 and did postdoctoral training at Yale University with Dr. Leonard Kaczmarek. In 2005 Bhattacharjee was appointed assistant professor at the University at Buffalo and currently he is an associate professor in Pharmacology and Toxicology. Bhattacharjee investigates how sodium-activated potassium channels contribute to neuronal firing in pain-sensing neurons, during inflammation and nerve injury. He has published 40 papers on ion channel biology and function.

Table of Contents

Table of Contents Basic Principles 1. Excitable Membrane Properties of Neurons Leonard K. Kaczmarek 2. Ion Channel Permeation and Selectivity Juan J. Nogueira and Ben Corry 3. Gating of Ion Channels Rene Barro-Soria Voltage-gated Channels 4. The Voltage-Dependent K+ Channel Family Hanne B. Rasmussen and James S. Trimmer 5. Potassium Channel Mutations in Epilepsy Elizabeth E. Palmer 6. The Voltage-Dependent Sodium Channel Family Mariola Zaleska, Samantha C. Salvage, Andrew J. Thompson, Sivakumar Namadurai, Christopher L.-H. Huang, Trevor Wilkinson, Fiona S. Cusdin, and Antony P. Jackson 7. Specialized Sodium Channels in Pain Transmission Yucheng Xiao, Zifan Pei, and Theodore R. Cummins 8. Sodium Channelopathies of the Central Nervous System Paul G. DeCaen, Alfred L. George, Jr., and Christopher H. Thompson Ligand-gated Channels 9. AMPA and Kainate Receptors G. Brent Dawe, Patricia M. G. E. Brown, and Derek Bowie 10. N-Methyl-D-Aspartate Receptors Gary J. Iacobucci and Gabriela K. Popescu 11. Nicotinic Acetylcholine Receptors Roger L. Papke 12. GABAA Receptor Physiology and Pharmacology Martin Wallner, A. Kerstin Lindemeyer, and Richard W. Olsen 13. P2X Receptors Annette Nicke, Thomas Grutter, and Terrance M. Egan 14. Large Conductance Potassium Channels in the Nervous System Willy Carrasquel-Ursulaez, Yenisleidy Lorenzo, Felipe Echeverria, and Ramon Latorre 15. Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels Alessio Masi, Maria Novella Romanelli, Guido Mannaioni, and Elisabetta Cerbai Other Channels 16. Tandem Pore Domain Potassium Channels Douglas A. Bayliss 17. TRPC Channels-- Insight from the Drosophila Light Sensitive Channels Ben Katz, William L. Pak, and Baruch Minke 18. Acid-Sensing Ion Channels Stefan Gründer 19. TMEM16 Ca2+ Activated Cl- Channels and CLC Chloride Channels and Transporters Anna Boccaccio and Michael Pusch