The HDL Handbook: Biological Functions and Clinical Implications

by Tsugikazu Komoda (Editor)

Overview

The HDL Handbook: Biological Functions to Clinical Implications brings laboratory research in HDL from bench to bedside in this needed resource for researchers and clinicians studying cholesterol, lipids, epidemiology, biochemistry, molecular medicine, and pathophysiology of cardiovascular diseases. In addition, researchers and clinicians working with an aging population, corporate researchers, post-doctorates; medical students and graduate students will find this publication useful because the scope of coverage includes basic science, genetics, epidemiology, and treatment of HDL cholesterol as well as potential targets to modify HDL cholesterol.

Product Details

ISBN-13:	9780124079243
Publisher:	Elsevier Science & Technology Books
Publication date:	10/16/2013
Sold by:	Barnes & Noble
Format:	eBook
Pages:	354
File size:	4 MB

About the Author

Dr. Komoda is a visiting professor at Toho University School of Medicine in Japan. He has extensive expertise with research in alkaline phosphatase, amylase, and oxidized HDL. He co-operated the intestinal alkaline phosphatase at Washington University School of Medicine in St. Louis, Missouri. He is the recipient of the Kodama Memorial Award from Japanese Society of Electrophoresis.

Table of Contents

Preface vii

List of Contributors ix

1 Role of Phospholipid Transfer Protein in HDL Remodeling and Atherosclerosis Hiroaki Hattori 1

2 The Role of Cholesteryl Ester Transfer Protein (CETP) in HDL Metabolism Neil J. Hime 17

3 Plasma Cholesteryl Ester Transfer Protein (CETP) in Relation to Human Pathophysiology Akihiro Inazu 35

4 HDL and Reverse Cholesterol Transport: Physiological Modulation Giovanna Catalano Maryse Guerin 61

5 Serum Paraoxonase (PON1) and its Interactions with HDL: Relationship between PON1 and Oxidative Stress Jelena Vekic Jelena Kotur-Stevuljevic Aleksandra Zeljkovic Aleksandra Stefanovic Zorana Jelic-lvanovic Slavica Spasic Vesna Spasojevic-Kalimanovska 77

6 Paraoxonase-1 and its Interactions with HDL: Molecular Structures of PON1 and HDL Daniel Rochu Eric Chabrière Patrick Masson 99

7 Apolipoprotein A-l Mutations Akira Matsunaga Yoshinari Uehara Bo Zhang Keijiro Saku 133

8 The Scavenger Receptor Class B Type I: An HDL Receptor Involved in Lipid Transport and HDL Dependent Signaling Aishah Al-Jarallah Rachelle Brunet Bernardo Trigatti 153

9 HDL Mimetic Peptides: Novel Therapeutic Strategies for the Treatment of Inflammatory Vascular Disease C. Roger White G.M. Anantharamaiah Geeta Datta 179

10 Sterol Efflux by ABCA1 and ABCG1 Naoki Terasaka 199

11 Functional Change in the HDL Particle by Oxidative Modification and its Contribution to Atherogenesis Toshiyuki Matsunaga Akira Hara Tsugikazu Komoda 215

12 Preβl-HDL, a Native Lipid-poor HDL, and its Potential as a New Marker for HDL Metabolism Takashi Miida Satoshi Hirayama 243

13 Determination of Circulating Native and Denaturated HDL Concentrations and its Clinical Implications Takanari Nakano Makoto Seo Tsugikazu Komoda 261

Index 277

What People are Saying About This

From the Publisher

Examines the basic science, genetics, epidemiology, and treatment of HDL cholesterol, including the latest advances in HDL cholesterol research

Editorial Reviews

Reviewer: Joseph A Randy Englert III, MD (Ochsner Clinic Foundation)
Description: This book provides in-depth analysis of the numerous biological roles and possible clinical implications of the high density lipoprotein (HDL) particle.
Purpose: The purpose is to bring information gathered through laboratory research in HDL from the bench to the bedside. The book is designed to be a valuable source for the development of clinical trials with the aim of improvement of HDL cholesterol levels and the prevention of cardiovascular events.
Audience: The audience includes both researchers and clinicians studying cholesterol, lipids, epidemiology, biochemistry, molecular medicine, and the pathophysiology of cardiovascular diseases.
Features: The book is well organized into 12 chapters that focus on bench-to-beside coverage of HDL with thorough analysis of basic science, genetics, epidemiology, and treatment. Each chapter concludes with references. This third edition covers the science of HDL metabolism including information on HDL cholesterol metabolism, gene expression, gene-bioactive compounds interaction, and post-translational modifications of gene expression of apolipoproteins. It also presents the latest advances in HDL cholesterol research with international perspectives. The text is supplemented by easy-to-read, colorful illustrations and graphs.
Assessment: This book accomplishes its goal of bringing laboratory research from the bench to the bedside in a format that can be used by researchers and clinicians alike who are studying HDL cholesterol.

Doody's Review Service

"Editor Komoda's research handbook for physicians and medical scientists addresses in detail the biochemistry and pathophysiology of high-density lipoprotein (HDL) cholesterol. The history of HDL research is summarized in the introduction, including its labeling as "good cholesterol" and recent questions problematizing that label." —ProtoView.com, January 2014

"This is one of the best available sources for a concise yet detailed review of the enormous data on HDL mechanics, genetics, and clinical implications…a very effective and focused presentation for a complex topic…This is an outstanding work. The book is unique in that it not only updates leaders in the field on new advances in HDL research, but it also can jump start beginners in the field." Rating: 4 Stars —Doody.com, February 28, 2014

From the Publisher