The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

by Lara V. Marks

Overview

The untold story of monoclonal antibodies—the molecular heroes of biotechnology that revolutionized the diagnosis and treatment of more than fifty major diseases

This book is the first to tell the extraordinary yet unheralded history of monoclonal antibodies. Often referred to as Mabs, they are unfamiliar to most nonscientists, yet these microscopic protein molecules are everywhere, quietly shaping our lives and healthcare. Discovered in the mid-1970s in the laboratory where Watson and Crick had earlier unveiled the structure of DNA, Mabs have radically changed understandings of the pathways of disease. They have enabled faster, cheaper, and more accurate clinical diagnostic testing on a vast scale. And they have played a fundamental role in pharmaceutical innovation, leading to such developments as recombinant interferon and insulin, and personalized drug therapies such as Herceptin. Today Mabs constitute six of the world’s top ten blockbuster drugs and make up a third of new introduced treatments.
 
Lara V. Marks recounts the risks and opposition that a daring handful of individuals faced while discovering and developing Mabs, and she addresses the related scientific, medical, technological, business, and social challenges that arose. She offers a saga of entrepreneurs whose persistence and creativity ultimately changed the healthcare landscape and brought untold relief to millions of patients. Even so, as Marks shows, controversies over Mabs remain, and she examines current debates over the costs and effectiveness of these innovative drugs.

Product Details

ISBN-13:	9780300167733
Publisher:	Yale University Press
Publication date:	06/30/2015
Pages:	344
Product dimensions:	6.10(w) x 9.30(h) x 1.20(d)

About the Author

Lara V. Marks is a historian of medicine. She is managing editor of the website whatisbiotechnology.org and has research affiliations with King’s College London and Cambridge University. She lives in Kent, UK.

Table of Contents

List of Illustrations ix

Preface xi

Acknowledgments xxi

List of Abbreviations xxv

1 Hunting for the Elusive "Magic Bullet" 1

2 A Hesitant Start: Patents, Politics, and Process 25

3 Breakthroughs at the Bench 47

4 The First Medical Applications 69

5 Joy, Disappointment, Determination: Early Clinical Tests 88

6 The Wild West of Antibody Commercialization 110

7 The Challenge of Monoclonal Antibody Drugs 139

8 Antibody Engineering: A Renaissance for Mab Therapeutics 159

9 Blockbuster Mab Drugs 184

10 A Quiet Revolution: The Legacy of Monoclonal Antibodies 218

Notes 237

Glossary 293

Bibliography 301

Index 307

Editorial Reviews

A masterful, original, and compelling account of how monoclonal antibodies progressed from a dicey laboratory technology to Nobel worthiness, and then were forged into a multibillion-dollar biomedical industry. A landmark history.”—Daniel J. Kevles, Stanley Woodward Professor of History, Yale University

Daniel J. Kevles

[W]ritten in an accessible style, Marks brings to life many of those who contributed to what she rightly describes as a transformative ability to understand, diagnose and treat disease.”—Sir Geoffrey Owen, Financial Times

Financial Times - Sir Geoffrey Owen

Relevant, authoritative, and accessible to an educated but non-expert reader, The Lock and Key of Medicine provides a fascinating history of the development of Mabs.”—Janice M. Reichert, Editor-in-Chief, mAbs

Janice M. Reichert

A fascinating picture of one of the most important advances in modern medicine. Lock and Key provides insights for researchers, policy-makers, and all who care about the future of medical science.”—Donald L. Drakeman, Centre for Health Leadership & Enterprise, University of Cambridge

Donald L. Drakeman

Lara Marks relates the 40-year history of monoclonal antibodies and also brilliantly captures the personalities and ideologies of the many individuals involved along with the clashes and controversies along the way.”—Mike Clark, Cambridge University

Mike Clark

Marks gives us a truly amazing story of medical knowledge, drug development, and biotechnology involving monoclonal antibodies. The quiet revolution in our current therapeutic and diagnostic tool kit, based on Mabs, is nothing short of awesome.”—William Summers, Yale University

William Summers

This unique, impressive and well-researched volume not only lays out the scientific basis underlying the monoclonal antibody revolution, but also deals sensitively with their evolution as commercial reagents and therapeutics.”—Herman Waldmann, Oxford University

Herman Waldmann

Extraordinary. . . . The amount of scholarship presented here is stunning, and constitutes a magnificent advance in the historiography of pharmacology and the pharmaceutical industry.”—Malcolm Nicolson, University of Glasgow

Malcolm Nicolson