Vaccines and Autoimmunity

by Yehuda Shoenfeld (Editor), Nancy Agmon-Levin (Editor), Lucija Tomljenovic (Editor)

Overview

In light of the discovery of Autoimmune Syndrome Induced by Adjuvants, or ASIA, Vaccines and Autoimmunity explores the role of adjuvants – specifically aluminum in different vaccines – and how they can induce diverse autoimmune clinical manifestations in genetically prone individuals.

Vaccines and Autoimmunity is divided into three sections; the first contextualizes the role of adjuvants in the framework of autoimmunity, covering the mechanism of action of adjuvants, experimental models of adjuvant induced autoimmune diseases, infections as adjuvants, the Gulf War Syndrome, sick-building syndrome (SBS), safe vaccines, toll-like receptors, TLRS in vaccines, pesticides as adjuvants, oil as adjuvant, mercury, aluminum and autoimmunity. The following section reviews literature on vaccines that have induced autoimmune conditions such as MMR and HBV, among others. The final section covers diseases in which vaccines were known to be the solicitor – for instance, systemic lupus erythematosus – and whether it can be induced by vaccines for MMR, HBV, HCV, and others.

Edited by leaders in the field, Vaccines and Autoimmunity is an invaluable resource for advanced students and researchers working in pathogenic and epidemiological studies.

Product Details

ISBN-13:	9781118663493
Publisher:	Wiley
Publication date:	05/11/2015
Sold by:	JOHN WILEY & SONS
Format:	eBook
Pages:	400
File size:	3 MB

About the Author

Yehuda Shoenfeld is the Incumbent of the Laura Schwarz-Kipp Chair of Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel Aviv University in Tel Aviv, Israel. He is also Founder of the Center for Autoimmune Diseases, both at the Sheba Medical Center in Tel Hashomer, Israel.

Nancy Agmon-Levin is a specialist in Clinical Immunology and Allergology, and serves as Deputy Head of the Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center in Tel Hashomer, Israel. She is also President of the Israel Association for Allergy and Clinical Immunology (IAACI).

Lucija Tomljenovic is a Senior Postdoctoral Fellow in the Neural Dynamics Research Group at the University of British Columbia in Vancouver, BC, Canada.

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Table of Contents

Contributors ix

Introduction 1
Yehuda Shoenfeld, Nancy Agmon-Levin and Lucija Tomljenovic

Part I: Mosaic of Autoimmunity

1 Role of Adjuvants in Infection and Autoimmunity 11
Eitan Israeli, Miri Blank, and Yehuda Shoenfeld

2 Infections as Adjuvants for Autoimmunity: The Adjuvant Effect 25
Quan M. Nhu and Noel R. Rose

3 Experimental Models of Adjuvants 35
Nicola Bassi, Mariele Gatto, Anna Ghirardello, and Andrea Doria

4 Answers to Common Misconceptions Regarding the Toxicity of Aluminum Adjuvants in Vaccines 43
Lucija Tomljenovic and Christopher A. Shaw

5 Allergy and Autoimmunity Caused by Metals: A Unifying Concept 57
Vera Stejskal

6 Genetics and Vaccinology 65
John Castiblanco and Juan-Manuel Anaya

7 Silicone and Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA) 79
Yair Levy and Rotem Baytner-Zamir

8 Silicone Breast Implants and Autoimmune/Inflammatory Syndrome induced by Adjuvants (ASIA): A Literature Search 87
Elisabetta Borella, Eitan Israeli, and Yehuda Shoenfeld

9 Autoantibodies Induced by Vaccine 93
Nataša Toplak and Tadej Av¢§cin

10 The ASIA Syndrome Registry 103
Ignasi Rodriguez-Pinto and Yehuda Shoenfeld

11 Vaccination in Autoimmune Diseases 107
Carla Goncalves, Schahin Saad, Clovis A. Silva, and Eloisa Bonfa

12 Vaccination in Patients with Autoimmune Inflammatory Rheumatic Diseases 113
Abdulla Watad, Alessandra Soriano, and Yehuda Shoenfeld

Part II: Studies on Autoimmune Conditions Induced by Vaccination

13 Measles, Mumps, and Rubella Vaccine: A Triad to Autoimmunity 129
Carlo Perricone, Guido Valesini, and Yehuda Shoenfeld

14 Yellow Fever Vaccine and Autoimmunity 135
Roger A. Levy and Rodrigo Poubel V. Rezende

15 Antiphospholipid Syndrome and Vaccines 141
Miri Blank and Paola Cruz-Tapias

16 Hepatitis B Vaccination and Autoimmunity 147
Daniel S. Smyk, Lazaros I. Sakkas, Yehuda Shoenfeld, and Dimitrios P. Bogdanos

17 Adverse Reactions to Human Papillomavirus Vaccines 163
Lucija Tomljenovic and Christopher A. Shaw

18 Influenza Vaccine and Autoimmune Diseases 175
Luis J. Jara, Gabriela Medina, Pilar Cruz Dominguez, Olga Vera-Lastra, Miguel A. Saavedra, Monica Vazquez del Mercado, and Minoru Satoh

19 Vaccines and Autoimmunity: Meningococcal Vaccines 185
Giovanna Passaro, Alessandra Soriano, and Raffaele Manna

20 Pneumococcal Vaccines and Autoimmune Phenomena 191
Elisabetta Borella, Nancy Agmon-Levin, Andrea Doria, and Yehuda Shoenfeld

21 BCG and Autoimmunity 197
Luigi Bernini, Carlo Umberto Manzini, and Clodoveo Ferri

Part III: Autoimmune Diseases Solicited by Vaccination

22 Systemic Lupus Erythematosus Induced by Vaccines 209
Nurit Katz-Agranov and Gisele Zandman-Goddard

23 Vasculitides 223
Alessandra Soriano, Rotem Inbar, Giovanna Passaro, and Raffaele Manna

24 Vaccinations in Rheumatoid Arthritis 233
Eitan Giat and Merav Lidar

25 Undifferentiated Connective-Tissue Diseases 247
Maria Martinelli, Carlo Perricone, and Yehuda Shoenfeld

26 Vaccines, Infections, and Alopecia Areata 255
Yaron Zafrir, Sharon Baum, Nancy Agmon-Levin, and Yehuda Shoenfeld

27 Aluminum Particle Biopersistence, Systemic Transport, and Long-Term Safety: Macrophagic Myofasciitis and Beyond 261
Romain K. Gherardi, Josette Cadusseau, and Francois-Jerome Authier

28 Immune Thrombocytopenic Purpura: Between Infections and Vaccinations 271
Carlo Perricone, Maurizio Rinaldi, Roberto Perricone, and Yehuda Shoenfeld

29 Vaccinations and Type 1 Diabetes 283
Alessandro Antonelli, Silvia Martina Ferrari, Andrea Di Domenicantonio, Ele Ferrannini, and Poupak Fallahi

30 Narcolepsy and H1N1 vaccine 291
María -Teresa Arango, Shaye Kivity, Nancy Agmon-Levin, Gili Givaty, Joab Chapman, and Yehuda Shoenfeld

31 Non-nutritional Environmental Factors Associated with Celiac Disease: Infections and Vaccinations 301
Aaron Lerner

32 Polymyalgia Rheumatica 307
Alessandra Soriano and Raffaele Manna

33 Acute Disseminated Encephalomyelitis: Idiopathic, Post-infectious, and Post-vaccination 311
Dimitrios Karussis and Panayiota Petrou

34 Fibromyalgia, Chronic Fatigue, Functional Disorders, and Vaccination: Where Do We Stand? 331
Jacob N. Ablin and Dan Buskila

35 Bullous Dermatoses, Infectious Agents, and Vaccines 337
Yaron Zafrir, Nancy Agmon-Levin, and Sharon Baum

36 Infections, Vaccinations, and Chronic Fatigue Syndrome 345
Hussein Mahagna, Naim Mahroum, and Howard Amital

37 Myositis and Vaccines 349
Ignasi Rodriguez-Pinto and Yehuda Shoenfeld

Index 359