When Glass meets Pharma: Insights about glass as primary packaging material

When Glass meets Pharma: Insights about glass as primary packaging material

by Dr. Bettine Boltres

NOOK Book1. Auflage, 2015 (eBook - 1. Auflage, 2015)

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Overview

Demands on a primary packaging material are not easy to meet these days. Increasingly, intense optical inspection, zero defect programs, and higher regulatory specifications require that drug packaging materials can no longer be taken for granted. Bringing us to the material "glass": What is glass anyway? How does it react with my drugs? Can I freeze it? Why is it breaking? Why is my drug being adsorbed to it? Why is this over 100-year-old borosilicate glass still the gold standard? If you have asked yourself these or other glass-related questions, this book is the right choice for you. It will guide you through the world of glass in a comprehensible and pharma-focused manner. Furthermore, this guide will keep you well-covered with the fundamentals on your first voyage into the world of glass. Die Anforderungen an Primaerpackmaterialien sind heutzutage nicht leicht zu erfuellen. Intensive optische Pruefungen, Null-Fehler-Programme und strengere Behoerdenanforderungen haben dazu gefuehrt, dass Hersteller ein erhoehtes Augenmerk auf Packmittel fuer Medikamente richten muessen. Nehmen wir zum Beispiel den Werkstoff Glas: Was ist Glas ueberhaupt? Wie reagiert es mit meinen Arzneimitteln? Kann ich es einfrieren? Warum geht es kaputt? Warum lagert sich mein Medikament auf der Glasoberflaeche an? Warum ist Borosilikat-Glas, das es schon seit über 100 Jahren gibt, immer noch der Goldstandard? Wenn Sie sich diese oder andere Fragen rund um Glas schon einmal gestellt haben, ist dieses Buch das richtige fuer Sie. Es wird Sie umfassend und aus dem pharmazeutischen Blickwinkel durch die Welt des Glases fuehren. Gleichzeitig wird dieses Handbuch Sie auf Ihrer ersten Reise in die Welt des Glases sicher geleiten und Ihnen alle Grundbegriffe erlaeutern.

Product Details

ISBN-13: 9783871934339
Publisher: ECV Editio Cantor
Publication date: 08/19/2015
Series: ecvINSIGHTS!
Sold by: Libreka GmbH
Format: NOOK Book
Pages: 80
File size: 9 MB

About the Author

Dr. Bettine Boltres works as product manager for SCHOTT Pharmaceutical Tubing. Since joining SCHOTT in 2010, her primary role has been to provide scientific support globally and to offer glass training for converters and pharmaceutical companies. In the past three years, she has given over seventy glass training programs for pharmaceutical companies, converters, and at universities. She is a frequent speaker at industry conferences and has chaired and moderated technical training events on glass for the parenteral drug association (PDA). She has also authored a number of articles for several international magazines. Dr. Boltres is a (bio)chemist by training, having received a diploma in chemistry from the university of Frankfurt, Germany and a PhD in biochemistry from the university of Cologne, Germany.

Table of Contents

Contents Preface 5 1. The nature of glass 1.1 Structure of glass 1.2 Chemical composition 1.3 Type I and Type III glass 1.4 Production of tubular and molded containers 2. Glass and heat 2.1 Viscosity 2.2 Stress 2.3 Coefficient of thermal expansion (CTE) 2.4 Thermal conductivity 2.5 Thermal shock resistance 2.6 Lyophilization 3. Glass and radiation and gases 3.1 Light transmission 3.2 Light protection 3.3 Gamma radiation 3.4 Permeability 4. Glass and liquids?chemical resistance 4.1 Reactions with acidic solutions 4.2 Reactions with basic solutions 4.3 Reactions with water 4.4 Testing methods for hydrolytic resistance 4.5 pH shift 4.6 Reactions with organic acids 4.7 Extractables and leachables 5. Glass surface reactions 5.1 Surface layer 5.2 Charge of the glass surface 5.3 Water contact angle 5.4 Weathering 5.5 Roughness 5.6 Sulfate surface treatment 5.7 Chemical toughening 5.8 Delamination 5.9 Protein adsorption 6. Glass strength 6.1 Ductile and brittle materials 6.2 Elasticity and plasticity 6.3 Stress and strain 6.4 Stiffness and modulus of elasticity 6.5 Hardness 6.6 Damage to glass 6.7 Crack growth 6.8 Breakage References

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