Bioorganic Chemistry: A Chemical Approach to Enzyme Action / Edition 3

by Hermann Dugas

Overview

New textbooks at all levels of chemistry appear with great regularity. So me fields such as basic biochemistry, organic reaction mechanisms, weIl represented by many excellent and chemical thermodynamics are texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the graduate level, suffer from areal lack of up-to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research that is advancing the field. It is not often easy to persuade such individuals to set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and per suade experts in these fields to produce relatively concise but instructive introductions to their fields. These should serve the needs of one semester or one quarter graduate courses in chemistry and biochemistry. In some cases the availability of texts in active research areas should help stimulate the creation of new courses. Charles R. Cantor vii Preface to the Third Edition It was over 100 years ago that Emil Fischer postulated his ingenious "lock-and-key" principle, whieh was subsequently applied to the development of a modern theory of enzyme catalysis.

Product Details

ISBN-13:	9780387989105
Publisher:	Springer New York
Publication date:	08/27/1999
Series:	Springer Advanced Texts in Chemistry
Edition description:	3rd ed. 1996. 2nd printing 1999
Pages:	700
Product dimensions:	6.10(w) x 9.25(h) x 0.05(d)

Table of Contents

1 Introduction to Bioorganic Chemistry.- 1.1 Basic Considerations.- 1.2 Proximity Effects in Organic Chemistry.- 1.3 Molecular Adaptation.- 1.4 Molecular Recognition and the Supramolecular Level.- 2 Bioorganic Chemistry of Amino Acids and Polypeptides.- 2.1 Chemistry of the Living Cells.- 2.2 Analogy Between Organic Reactions and Biochemical Transformations.- 2.3 Chemistry of the Peptide Bond.- 2.4 Nonribosomal Peptide Bond Formation.- 2.5 Asymmetric Synthesis of—-Amino Acids.- 2.6 Asymmetric Synthesis with Chiral Organometallic Catalysts.- 2.7 Transition State Analogs.- 2.8 Antibodies as Enzymes.- 2.9 Chemical Mutations.- 2.10 Molecular Recognition and Drug Design.- 3 Bioorganic Chemistry of the Phosphate Groups and Polynucleotides.- 3.1 Basic Considerations.- 3.2 Energy Storage.- 3.3 Hydrolytic Pathways and Pseudorotation.- 3.4 DNA Intercalants.- 4 Enzyme Chemistry.- 4.1 Introduction to Catalysis.- 4.2 Introduction to Enzymes.- 4.3 Multifunctional Catalysis and Simple Models.- 4.4—-Chymotrypsin.- 4.5 Other Hydrolytic Enzymes.- 4.6 Stereoelectronic Control in Hydrolytic Reactions.- 4.7 Immobilized Enzymes and Enzyme Technology.- 4.8 Enzymes in Synthetic Organic Chemistry.- 4.9 Enzyme-Analog-Built Polymers.- 4.10 Design of Molecular Clefts.- 5 Enzyme Models.- 5.1 Host-Guest Complexation Chemistry.- 5.2 New Developments in Crown Ether Chemistry.- 5.3 Membrane Chemistry and Micelles.- 5.4 Polymers.- 5.5 Cyclodextrins.- 5.6 Enzyme Design Using Steroid Template.- 5.7 Remote Functionalization Reactions.- 5.8 Biomimetic Polyene Cyclizations.- 6 Metal Ions.- 6.1 Metal Ions in Proteins and Biological Molecules.- 6.2 Carboxypeptidase A and the Role of Zinc.- 6.3 Hydrolysis of Amino Acid Esters and Amides and Peptides.- 6.4 Iron and Oxygen Transport.- 6.5 Copper Ion.- 6.6Biomodels of Photosynthesis and Energy Transfer.- 6.7 Cobalt and Vitamin B12 Action.- 7 Coenzyme Chemistry.- 7.1 Oxidoreduction.- 7.2 Pyridoxal Phosphate.- 7.3 Suicide Enzyme Inactivators and Affinity Labels.- 7.4 Thiamine Pyrophosphate.- 7.5 Biotin.- 8 Molecular Devices.- 8.1 Introduction to Self-Organization and Self-Assembly.- 8.2 General Overview of the Approach.- 8.3 Specific Examples.- References.