Stereoselectivity in Synthesis / Edition 1

by Tse-Lok Ho

Overview

Many chemicals are found in "right-" and "left-handed" forms that may react differently in the body. In planning a synthesis, chemists must know how to select the best method for making the preferred form of a chemical. This book shows how to choose the best method for a given synthesis. It provides readers with a thorough understanding of stereoselectivity in organic and medicinal chemistry as well as the pharmaceutical, agricultural, and food industries.

Product Details

ISBN-13:	9780471329220
Publisher:	Wiley
Publication date:	03/25/1999
Pages:	352
Product dimensions:	6.40(w) x 9.52(h) x 0.80(d)

About the Author

TSE-LOK HO is Professor of Organic Chemistry at National Chiao Tung University in Taiwan. His research interests are in organic synthesis, including total synthesis of natural products and methodology. He has written 12 books, including, most recently, Stereoselectivity in Synthesis, available from Wiley. Dr. Ho holds degrees from National Taiwan University and the University of New Brunswick, Canada.

Table of Contents

Some Fundamental Concepts.

1,2-Stereoinduction.

1,3-Stereoinduction.

Stereoinduction at Long Distances.

Group Directed Reactions and Chelation Effects.

Conformational Effects.

Topographical and Template Effects.

Steric, Electrostatic, and Stereoelectronic Effects.

Thermodynamic Control and Kinetic Trapping.

Index.

Editorial Reviews

"...research workers in this field will either wish to purchase this book or to have ready access to a copy" (Applied Organometallic Chemistry, Vol 15, 2001)

From the Publisher

...research workers in this field will either wish to purchase this book or to have ready access to a copy.

Applied Organometallic Chemistry

Offers a systematic review of the literature on stereoselective synthesis, addressing the proliferation of methodologies related to reaction stereoselectivity. Presents hundreds of reaction schemes with clear stereochemical features, focusing on substrate-induced stereoselective transformations. Examples of synthesis of complex natural products illustrate basic principles of organic stereochemistry and its application and show how to solve stereochemical problems in organic and medicinal chemistry as well as in the pharmaceutical, agricultural, and food industries. Annotation c. by Book News, Inc., Portland, Or.

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