The Cytokine Handbook, Two-Volume Set

by Angus W. Thomson (Editor), Michael T. Lotze (Editor)

Overview

The fourth edition of The Cytokine Handbook provides an encyclopedic coverage of the molecules that induce and regulate immune responses. Now expanded to two volumes, co-edited by Michael T Lotze, and written by over 120 international experts, the scope of the book has been broadened to include a major emphasis on the clinical applications of cytokines. The early chapters discuss individual cytokines, chemokines and receptors. Additional chapters discuss the clinical implications and applications of cytokines, including cytokine gene transfer, antisense therapy and assay systems. This book is essential for researchers and clinicians interested in cytokines, including anyone working in cancer biology, transplantation, infectious diseases, autoimmunity or bioinformatics.Key Features* Covers all main cytokines and chemokines * Written by experts* Up-to-date- includes detailed referencing accessing current, modern literature and reflects the newest findings from the human genome * The new edition has been thoroughly revised and extended (now 2 volumes) as compared to the last edition, including new co-editor (MTL), new authors, new hot topics and new chapters* Includes major emphasis on clinical applications* Extensively illustrated with tables and figures

Product Details

ISBN-13:	9780080518794
Publisher:	Elsevier Science & Technology Books
Publication date:	04/22/2003
Sold by:	Barnes & Noble
Format:	eBook
Pages:	1572
File size:	18 MB
Note:	This product may take a few minutes to download.

About the Author

Thomson, Angus W., MD (Univ of Pittsburgh)

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A two-volume set that covers all main cytokines and chemokines.

Table of Contents

Volume 1PrefaceForewardSection I Basic Cytokine Biology1Cytokines Overview2Cytokine Genetics3The Phylogeny of Cytokines4Cytokine SignallingSection II The Cytokines and ChemokinesSubsection A. The Hematopoietin Family Members5Growth Hormone and its Receptors6Prolactin7Erythropoietin8Interleukin 29Interleukin 310Interleukin 411Interleukin 512Interleukin 613Interleukin 714Interleukin 915Interleukin 1116Interleukin 12 Family: IL-12 17Interleukin 1318Interleukin 15 and Interleukin 2119Interleukin 1620Interleukin 1721Granulocyte-Macrophage 22Granulocyte Colony-Stimulating Factor and its Receptor 23M-CSF Subsection B. The Interferon Family Members24Type I Interferons25Interferon-g26Interleukin 1027Interleukins 19, 20, 22, 24 and 26 Volume II. Subsection C. The beta trefoil cytokines28Interleukin 1 a and b29Interleukin 1 Receptor Antagonist30Novel Interleukin-1 Homologues31Interleukin 1832The Fibroblast Growth Factors33The Hepatocyte Growth Factor The HGF Receptor, MET34Toll-like Receptors: The Origins of Inflammation35Lymphotoxins36Tumor Necrosis Factor37TRAIL/apo2L38RANK-L : Receptor Activator of NF-kB Ligan39CD95L/FasL its receptor CD95 (APO-1/Fas)40HMGB-1/Amphoterin41EGF Family Ligand42FLT3 Ligand43Stem Cell Factor44Vascular Endothelial Growth Factor45Macrophage Migration Inhibitory Factor (MIF)46Interleukin-8 and other CXC Chemokines47C-C Chemokines48Fractalkine-A Cell Surface Chemokines49Transforming Growth Factor b50Inhibin/Activin Family51Bone Morphogenic ProteinsSection III. Clinical Application of Cytokines and Cytokine Inhibition52Autoimmunity and Cytokines: Pathogenesis and Therapy53Cytokines and Cancer Caligiuri54Interferon alpha: biology, pharmacology, and therapy for chronic viral hepatitis55Haemopoietic Cytokines56Antiangiogenesis57Transplantation58Cytokines and Asthma59Cytokine Gene Transfer60Antisense Therapy61Assays for Cytokines

What People are Saying About This

From the Publisher

A two-volume set that covers all main cytokines and chemokines.

Editorial Reviews

4 Stars! from Doody

Thirty-three chapters provide coverage of the hemopoietic growth factors, 18 interleukin molecules, and the interferon family of molecules. Each treatment discusses in detail the immunology, molecular biology, and receptors of the molecules. Additional chapters treat stem cell factor; gene therapy; the chemokines; Flt3 ligand; and the therapeutic potential, assay systems, and phylogeny of the molecules. Annotation c. by Book News, Inc., Portland, Or.

Booknews

"Thompson and Lotze are to be commended for compiling this comprehensive work...The editors and authors should be commended for this very difficult task in this rapidly advancing field. There are excellent chapters on cytokine genetics, chemokine nomenclature, and the basic biology of each of the cytokines."
-ASM NEWS (April 2004)

From the Publisher

Reviewer: Marion C. Cohen, PhD (SUNY Downstate Medical Center)
Description: This is the fourth edition of a two-volume set attempts to give a detailed and up-to-date description of those regulatory molecules known as cytokines. At the rate at which this field expands, this revision is certainly welcome. The book begins with basic cytokine biology and then provides chapters on individual families of cytokines. The final section focuses on clinical application of cytokines and cytokine inhibition. The previous edition was published in 1998.
Purpose: The goal is to provide up-to-date coverage of all aspects of the cytokine field, a goal that cannot be completely achieved since it is a moving target. However, the editors and authors have achieved a high level of success and the chapters are as current as can be expected given the time it takes to produce any book and particularly one that is multi-authored. This new edition will be a useful source of information to many scientists whether they are familiar with the field or are neophytes.
Audience: The book is primarily written for researchers who need information about cytokines irrespective of their primary discipline. Advanced undergraduates and graduate students will also find a wealth of information that they might need. There is a section on applications that might be useful to clinicians. The first three editions were edited by Angus W. Thomson. For this fourth edition he has been joined by Michael T. Lotze. Both of them are well recognized authorities in the field. The authors of the individual chapters have been well chosen for their expertise.
Features: The first volume begins with basic cytokine biology and is followed by sections devoted to each of the cytokine families. Each family is divided into chapters describing individual cytokines or small groups of related cytokines. The final section deals with clinical application of cytokines and inhibition of their action. References are provided but of necessity they are limited in number. Nonetheless, it is likely that somewhere in these volumes is whatever one needs to know about cytokines or at least a reference that is helpful. There are some black-and-white figures as well as tables where appropriate. There are also some well done color illustrations grouped together in the center of each volume rather than within the chapter to which they belong. Presumably this is to keep costs down but it is somewhat distracting to the reader.
Assessment: These volumes provide a major well written source of information about cytokines. Although there have been other books that focused on cytokines in the past, there seems to be no competition at the moment. The year 2004 is the 30th anniversary of the first mention of the word "cytokine" (Cellular Immunology 12:150-159, 1974) and this book represents a timely reference for anyone interested in this area of biology.

Doody's Review Service