Medicinal Natural Products: A Biosynthetic Approach [NOOK Book]

Overview

Medicinal Natural Products: A Biosynthetic Approach, Third Edition, provides a comprehensive and balanced introduction to natural products from a biosynthetic perspective, focussing on the metabolic sequences leading to various classes of natural products. The book builds upon fundamental chemical principles and guides the reader through a wealth of diverse natural metabolites with particular emphasis on those used in medicine.

There have been rapid advances in biosynthetic ...

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Medicinal Natural Products: A Biosynthetic Approach

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Overview

Medicinal Natural Products: A Biosynthetic Approach, Third Edition, provides a comprehensive and balanced introduction to natural products from a biosynthetic perspective, focussing on the metabolic sequences leading to various classes of natural products. The book builds upon fundamental chemical principles and guides the reader through a wealth of diverse natural metabolites with particular emphasis on those used in medicine.

There have been rapid advances in biosynthetic understanding over the past decade through enzymology, gene isolation and genetic engineering. Medicinal Natural Products has been extended and fully updated in this new edition to reflect and explain these developments and other advances in the field. It retains the user-friendly style and highly acclaimed features of previous editions:

  • a comprehensive treatment of plant, microbial, and animal natural products in one volume
  • extensive use of chemical schemes with annotated mechanistic explanations
  • cross-referencing to emphasize links and similarities
  • boxed topics giving further details of medicinal materials, covering sources, production methods, use as drugs, semi-synthetic derivatives and synthetic analogues, and modes of action

Medicinal Natural Products: A Biosynthetic Approach, Third Edition, is an invaluable textbook for students of pharmacy, pharmacognosy, medicinal chemistry, biochemistry and natural products chemistry.

"...a concise and informative textbook providing a comprehensive introduction to natural products in medicine from a biosynthetic point of view."

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Editorial Reviews

Booknews
A text for an undergraduate pharmacy course reflecting the recent tendency to teach about pharmaceuticals derived from plants, antibiotics from microbials, and steroidal and prostanoid drugs from animals as a single subject. Pivots on the notion of biosynthesis as the metabolic sequence leading to various selected classes of natural products. Applies fundamental chemical principles and shows the relationships between the various structures encountered in nature to provide a rationale for natural products. Seeks more to engender an understanding of the structures and how living organisms put them together than to transfer a mass of descriptive information. The material is ample and diverse enough to be selected from to tailor a specific course. References are not only chapter-specific, but classified into the several compounds discussed. Annotation c. by Book News, Inc., Portland, Or.
From The Critics
This comprehensive guide to pharmacognosy, the scientific study of natural health remedies from herbs, animal products, and inorganic materials, is directed primarily toward undergraduate students— whether or not such material is integrated with traditional pharmacy courses. Dewick (pharmaceutical sciences, U. of Nottingham, UK) provides a foundation in natural product chemistry/phytochemistry and nomenclature before proceeding to coverage of the primary and secondary metabolism of the reactions of these diverse substances; and the pathways involved in the biosynthesis of several classes of popular natural medicines represented by echinacea, kava, feverfew, taxol, alkaloids, garlic, and various vitamins. The chapters include molecular structure diagrams, boxed material, and further reading. Annotation c. Book News, Inc., Portland, OR (booknews.com)
From the Publisher
"Students should be empowered for a deductive analysis of the presented substances." (Arzneimittelforschung, December 2009)

"This new edition is an excellent text that is unrivaled in both its scope and overall coverage of natural products biosynthesis." (Journal of Medicinal Chemistry, August 2009)

"There is no question that this is the best book available on the biosynthesis and bio-organic chemistry of medicinally important natural products." (Education in Chemistry, September 2009)

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Product Details

  • ISBN-13: 9781119964575
  • Publisher: Wiley
  • Publication date: 9/20/2011
  • Sold by: Barnes & Noble
  • Format: eBook
  • Edition number: 3
  • Pages: 550
  • File size: 29 MB
  • Note: This product may take a few minutes to download.

Table of Contents

1. ABOUT THIS BOOK, AND HOW TO USE IT.

The Subject.

The Aim.

The Approach.

The Topics.

The Figures.

Further Reading.

What to Study.

What to Learn.

Nomenclature.

Conventions Regarding Acids, Bases, and Ions.

Some Common Abbreviations.

Further Reading.

2. SECONDARY METABOLISM: THE BUILDING BLOCKS AND CONSTRUCTION MECHANISMS.

Primary and Secondary Metabolism.

The Building Blocks.

The Construction Mechanisms.

Alkylation Reactions: Nucleophilic Substitution.

Dehydrogenases.

Oxidases.

Monooxygenases.

Dioxygenases.

Amine Oxidases.

Baeyer-Villiger Monooxygenases.

Some Vitamins Associated with the Construction Mechanisms.

Elucidating Biosynthetic Pathways.

Further Reading.

3. THE ACETATE PATHWAY: FATTY ACIDS AND POLYKETIDES.

Fatty Acid Synthase: Saturated Fatty Acids.

Unsaturated Fatty Acids.

Uncommon Fatty Acids.

Prostaglandins.

Thromboxanes.

Leukotrienes.

Polyketide Synthases: Generalities.

Polyketide Synthases: Macrolides.

Macrolide Antibiotics, Erythromycins, Oleandomycin and Spiramycin, Tylosin, Avermectins, Polyene Antifungals, Tacrolimus and Sirolimus, Rifamycins.

Polyketide Synthases: Linear Polyketides and Polyethers.

Diels-Alder Cyclizations.

Polyketide Synthases: Aromatics.

Senna, Hypericum / St John's Wort, Mycophenolic acid, Khellin and Cromoglicate, Griseofulvin.

Poison Ivy and Poison Oak, Cannabis, Aflatoxins, Tetracyclines, Anthracycline Antibiotics.

Further Reading.

4. THE SHIKIMATE PATHWAY: AROMATIC AMINO ACIDS AND PHENYLPROPANOIDS.

Aromatic Amino Acids and Simple Benzoic Acids.

Phenylpropanoids.

Cinnamic Acids and Esters.

Lignans and Lignin.

Phenylpropenes.

Benzoic Acids from C6C3 Compounds.

Coumarins.

Aromatic Polyketides.

Styrylpyrones, Diarylheptanoids.

Flavonoids and Stilbenes.

Flavonolignans.

Isoflavonoids.

Terpenoid Quinones.

Further Reading.

5. THE MEVALONATE AND METHYLERYTHRITOL PHOSPHATE PATHWAYS: TERPENOIDS AND STEROIDS.

Mevalonic Acid and Methylerythritol Phosphate.

Hemiterpenes.

Monoterpenes.

Irregular Monoterpenes.

Iridoids.

Sesquiterpenes.

Artemisinin, Gossypol, Trichothecenes.

Diterpenes.

Sesterterpenes.

Triterpenes.

Steroids.

Stereochemistry and Nomenclature.

Cholesterol.

Phytosterols.

Vitamin D.

Steroidal Saponins.

Cardioactive Glycosides.

Bile Acids.

Adrenocortical Hormones/Corticosteroids.

Semi-Synthesis of Corticosteroids.

Progestogens.

Oestrogens.

Androgens.

Tetraterpenes.

Higher Terpenoids.

Further Reading.

6. ALKALOIDS.

Alkaloids Derived from Ornithine.

Alkaloids Derived from Lysine.

Alkaloids Derived from Nicotinic Acid.

Alkaloids Derived from Tyrosine.

Phenylethylamines and Simple Tetrahydroisoquinoline Alkaloids.

Modified Benzyltetrahydroisoquinoline Alkaloids.

Phenethylisoquinoline Alkaloids.

Terpenoid Tetrahydroisoquinoline Alkaloids.

Amaryllidaceae Alkaloids.

Alkaloids Derived from Tryptophan.

Simple Indole Alkaloids.

Simple - Carboline Alkaloids.

Terpenoid Indole Alkaloids.

Quinoline Alkaloids.

Pyrroloindole Alkaloids.

Ergot Alkaloids.

Alkaloids Derived from Anthranilic Acid.

Alkaloids Derived From Histidine.

Alkaloids Derived by Amination Reactions.

Acetate-Derived Alkaloids.

Phenylalanine-Derived Alkaloids.

Terpenoid Alkaloids.

Steroidal Alkaloids.

Purine Alkaloids.

Further Reading.

7. PEPTIDES, PROTEINS, AND OTHER AMINO ACID DERIVATIVES.

Peptides and Proteins.

Ribosomal Peptide Biosynthesis.

Peptide Hormones.

Thyroid Hormones.

Hypothalamic Hormones.

Hormone, Growth Hormone-releasing Hormone/Factor, Somatostatin.

Anterior Pituitory Hormones.

Posterior Pituitory Hormones.

Pancreatic Hormones.

Interferons.

Opioid Peptides.

Ribosomal Peptide Toxins.

Death Cap (Amanita phalloides), Ricin, Botulinum Toxin, Conotoxins, Snake Venoms, Gila Monster Venom.

Enzymes.

Nonribosomal Peptide Biosynthesis.

Bacitracins, Capreomycin, Polymyxins, Daptomycin, Cyclosporins, Vancomycin and Teicoplanin, Bleomycin, Streptogramins, Dactinomycin, Cycloserine.

Modified Peptides: Penicillins, Cephalosporins and Other ?-Lactams.

Cyanogenic Glycosides.

Glucosinolates.

Cysteine Sulphoxides.

Further Reading.

8. CARBOHYDRATES.

Monosaccharides.

Oligosaccharides.

Polysaccharides.

Aminosugars and Aminoglycosides.

Aminoglycoside Antibiotics, Streptamine-containing Antibiotics, 2-Deoxystreptamine-containing Antibiotics, Acarbose, Lincomycin and Clindamycin.

Further Reading.

Index.

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