Mucosal Vaccines

by Hiroshi Kiyono, Pearay L. Ogra (Editor), Jerry R. McGhee (Editor)

Overview

This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. - Provides the latest views on mucosal vaccines - Applies basic principles to the development of new vaccines - Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases - Unique and user-friendly organization

Product Details

ISBN-13:	9780080537054
Publisher:	Elsevier Science & Technology Books
Publication date:	10/23/1996
Sold by:	Barnes & Noble
Format:	eBook
Pages:	479
File size:	10 MB

About the Author

University of Alabama, Birmingham, U.S.A. and Osaka University, JapanSince the 1970s, Professor Kiyono has been investigating and characterizing unique features of the mucosal immune system to establish mucosal immunology as an area of the immunology field as well as to develop effective and safe mucosal vaccines against infectious diseases and mucosal immune therapies against allergic and inflammatory diseases. He recently developed cold-chain- and needle-free rice-based vaccines (MucoRice) with the cooperation of agricultural researchers. The vaccine antigens exogenously expressed in MucoRice are temperature-stable for at least 2.5 years and are resistant to digestive enzymes, thus they effectively induce vaccine antigen-specific protective immunity in both systemic and mucosal compartments against toxins produced by pathogenic microorganisms (e.g., cholera toxins). Additionally, his efforts aim to clarify the immunological cross-talk between the mucosal immune system and mucosal environmental factors (e.g., commensal bacteria and dietary materials) in immunological homeostasis. These studies will lead to the development of novel immune therapies against mucosal immune diseases, such as food allergy, rhinitis, and inflammatory bowel diseases.

Table of Contents

Introduction:P.L. Ogra, Mucosal Immunoprophylaxis.Principles of Mucosal Vaccination:J.R. McGhee, Mucosal Vaccines: From Molecular and Cellular Concepts of Mucosal Immunity to Practical Application.M.R. Neutra and J.-P. Kraehenbuhl, Antigen Uptake by M Cells for Effective Mucosal Vaccines.Mucosal Modulation for Induction of Effective Immunity:C.O. Elson, Cholera Toxin as a Mucosal Adjuvant.J.D. Clements, Unique Characteristics of Escherichia coli Heart-Labile Enterotoxin for Mucosal Immunization.H. Kiyono and C. Czerkinsky, Mucosal Vaccines and Oral Tolerance.Current and New Approaches for Mucosal Vaccine Delivery:R. Curtiss III, Attenuated Salmonella as Vectors for Oral Immunization.J. Ulmer, Current View of DNA Immunization for Mucosal Vaccines.S. Langermann, Recombinant BCG as Vector for Mucosal Immunity.C. Morrow, Recombinant Polio as Mucosal Vector.K. Rosenthal, Recombinant Adenovirus as Vector for Mucosal Immunity.R. Gilley, Current View of Microspheres as Mucosal Antigen Delivery System.M. Tomasi, ISCOMS, Liposomes and Oil Based Delivery Systems.S. Hamada and Y. Kodama, Application of Passive Immunity for Mucosal Vaccination.Mucosal Vaccines for Bacterial Diseases:M.R. Levine and M. Sztein, Human Mucosal Vaccines for Salmonella typhi Infection.A.A. Lindberg and T. Pal, Oral Vaccine for Shigella.J.J. Mekalanos, Live, Attenuated Cholera Vaccine.J.R. Holmgren and A.-M. Svennerholm, Oral Cholera and Enterotoxigenic E. coli Vaccines.P.B. Ernst and S. Czinn, Mucosal Immunity to Helicobacter pylori.D. Hoft, Oral BCG.Mucosal Vaccines for Viral Diseases:P.L. Ogra, Polio Viruses and Mucosal Vaccines.P.F. Wright, Mucosal RSV Vaccines.R.B. Couch, Mucosal Influenza Vaccines.R.B. Belshe, Mucosal Parainfluenza Vaccine.M. Conner, M.K. Estes, H. Greenberg, P. Offit, and H.F. Clark, Development of a Mucosal Rotaviros Vaccine.A.Z. Kapikian, Rotavirus Vaccines--The Clinical Experience.C. Miller and T. Lehner, Rectal and Vaginal Immunization for HIV/SIV.Site-Directed Mucsal Vaccine:C. Wira, Mucosal Immunity in the Female Reproductive System.C. Svanborg, Mucosal Immunity in the Urinary System.P. Montgomery and J. Whittum-Hudson, Mucosal Immunity in the Ocular System.S. Tamura and T. Kurata, Intranasal Immunization with Influenza Vaccine.R.J. Genco and R.C. Page, Mucosal Immunity for Oral Diseases.D.J. Lim and G. Morg, Mucosal Immunity in the Middle Ear.Subject Index.

Editorial Reviews

The emergence of new pathogens and drug-resistant strains of previously known pathogens suggests that new and effective vaccines should be developed for the prevention of disease. "Because mucosal surfaces are in constant contact with the environment and therefore are effectively used as portals of entry by a number of pathogens, new approaches to induce mucosal immunity need to be developed. This book contains several chapters providing a good overall view of the cellular structure and function of the mucosal immune system. The remaining chapters provide a good, broad foundation for understanding the current problems in vaccine research as well as a detailed description of cutting edge research on vaccines against specific mucosal pathogens and vaccines designed to protect specific mucosal sites. The editors have therefore succeeded in summarizing current views and concepts relating to new generations of vaccines and vaccine technologies. "The information contained in this book should be useful to both clinical and basic researchers interested in basic immunology or vaccine development. "Included in each chapter are well-designed illustrations that are of value in understanding the cellular and molecular events described in the text. The chapters are adequately referenced and the literature cited is very current. An index is included that should be somewhat helpful for those wishing to find specific information. The editors have selected appropriate and recognized experts in the field of mucosal immunology and mucosal vaccines. "This book should be a very useful tool for both clinical and basic researchers interested in vaccine approaches to protection of mucosal surfaces.

Gregg N. Milligan

Discusses all facets of mucosal vaccines, including their development, mechanisms of action, molecular and cellular aspects, and practical applications. Among the major topics are the principles of musocal vaccination, delivery approaches, bacterial and viral diseases, site-directed vaccines, and mucosal modulation for inducing effective immunity. Addressed to both basic scientists and clinical scholars in immunology, the basic biology of the mucosal immune system, or vaccines. Annotation c. by Book News, Inc., Portland, Or.

Booknews

"This book contains several chapters providing a good overall view of the cellular structure and function of the mucosal immune system. The remaining chapters provide a good, broad foundation for understanding the current problems in vaccine research as well as a detailed description of cutting edge research on vaccines against specific mucosal pathogens and vaccines designed to protect specific mucosal sites. The editors have therefore succeeded in summarizing current views and concepts relating to new generations of vaccines and vaccine technologies." —DOODY'S

"In the preface to this book, the editors state that "Mucosal Vaccines summarizes the most current and updated views and concepts related to the development of new generations of vaccines.' This tall order is beautifully delivered in 33 chapters and almost 500 pages by contributing authors, all respected experts in their fields... The editors have done an excellent job of putting together the many chapters in logical and understandable groupings, and the authors should be cited for their excellent contributions." —ASM NEWS

From the Publisher