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Understanding the Host Immune Response Against Mycobacterium tuberculosis Infection

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According to the World Health Organization, approximately one third of the world’s population is latently infected with Mycobacterium tuberculosis (M. tb [LTBI]), of whom about 9 million have active tuberculosis (TB). It is estimated that approximately 2 million individuals die each year from active TB. An estimated 14.4% of these individuals have HIV and M. tb co-infection.

TB has long been known to be one of the leading causes of death in HIV-infected individuals. Recent evidence now ind...