Cytochromes P-450 and b5: Structure, Function, and Interaction

P-450 has in common with our nation that it can call Phila­ delphia its hometown. Yet there are differences, too. The U. S. A. was born and named in this city. P-450 was first recog­ nized here — an odd CO-combining pigment without family or func­ tion. Japanese workers identified it as an unusual member of the cyhrome family. Finally, in Philadelphia, its biological func­ tion was established and its growth to a global power initiated. Since discovery of its function as terminal oxidase of...