Free Radical Reactions in Medicine

by Janos Feher, Geza Csomos, Andras Vereckei

Overview

This book aims to provide a concise review of the medical aspects of free radical reactions. Until now, there have been extensive reviews of the subject in a physiological, pathophysiological and biochemical context. Here, however, the authors concentrate on the biology of free radical reactions as relevant to medical practice, emphasizing that the topic is not just a branch of basic science. Consequently, a short introduction on chemical and biological aspects is followed by a detailed discussion of the role played by free radical reactions in the pathogenesis and development of several human diseases and in therapeutic possibilities. The summary of data from the literature is supplemented by the authors' own experimental results. The presentation will help medical researchers to notice so far unknown connections among several diseases and to make them aware of the existance of the so-called "free radical diseases".

Product Details

ISBN-13:	9783642831065
Publisher:	Springer Berlin Heidelberg
Publication date:	12/15/2011
Edition description:	Softcover reprint of the original 1st ed. 1987
Pages:	199
Product dimensions:	6.69(w) x 9.61(h) x 0.02(d)

Table of Contents

I The Chemistry of Free Radical Reactions.- 1 The Definition and Reactions of Free Radicals.- 2 Lipid Peroxidation.- 3 The Most Important Physical and Chemical Properties of Molecular Oxygen: Radicals of Molecular Oxygen.- 4 Reactions in which ROIs are Formed.- 5 Summary.- II Control of Free Radical Reactions in Biological Systems.- 1 Control by Membrane Structure.- 2 Control by Specific Molecular Structure.- 3 Scavengers and Antioxidants.- 4 Cellular Enzymatic Defence Against Radicals of Molecular Oxygen.- 5 Antioxidant Defence of the Extracellular Space.- 6 Summary.- III Physiological Free Radical Reactions.- 1 The Role of Free Radical Reactions in Phagocytosis.- 2 Free Radicals Generated During Platelet Activity.- 3 Free Radical Generation in Mihondrial and Microsomal Electron Transport Chains and in Peroxisomes.- 4 Role of Free Radicals in the Synthesis and Degradation of Various Biomolecules: Free Radical Formation During Autoexidation of Biomolecules.- 5 The Role of Free Radicals in Reproduction and Embryonic Development.- 6 Summary.- IV Pathological Free Radical Reactions: General Aspects.- 1 Damage of Enzymes and Proteins Caused by Free Radicals.- 2 Damage of the Cell Membrane and Subcellular Organelles.- 3 Fluorescent Molecular Damage and Lipofuscin Pigments.- 4 Free Radical Damage of Nucleic Acids and Their Components.- 5 Connection Between LPO and Tissue Damage.- 6 Summary.- V Demonstration of Free Radical Reactions.- 1 Summary.- VI Clinical Importance of Free Radical Reactions and Their Role in the Pathogenesis of Various Human Diseases.- 1 The Radical Theory of Oxygen Toxicity.- 2 The Role of Free Radical Reactions in Inflammation.- 3 Relation of Free Radical Reactions to the Immune System and Their Role in Immunopathological Syndromes.- 4 The Free Radical Theory of Ageing.- 5 The Role of Free Radical Reactions in the Pathogenesis of Some Neurological Diseases.- 6 The Free Radical Pathogenesis of Atherosclerosis.- 7 Hypertension and Free Radical Reactions.- 8 Free Radical Reaction in Ischaemic Damage.- 9 Free Radical Reactions in Other, Nonischaemic Heart Diseases.- 10 The Role of Free Radical Reactions in Carcinogenesis: Connection Between Atherosclerosis, Ageing, Carcinogenesis and Mutagenesis.- 11 Free Radical Reactions and Mutagenesis.- 12 Free Radical Mechanisms in the Effect of Drugs and Chemicals.- 13 Free Radical Reactions in Pulmonary Diseases.- 14 Free Radical Reactions in Hepatic Diseases.- 15 Free Radical Reactions in Diseases of the Gastrointestinal Traet.- 16 Free Radical Pathogenesis of Amyloidosis.- 17 Diabetes Mellitus and Pathological Free Radical Reactions.- 18 Haematological Aspects.- 19 Free Radical Reactions in Neonatal Diseases.- 20 Free Radical Reactions in Infectious Diseases.- 21 Hormones and Free Radical Reactions.- 22 Ophthalmological Aspects.- 23 Free Radical Reactions in Muscular Dystrophy.- 24 Free Radical Reactions in Pyelonephritis, Uraemia and urological Diseases.- 25 Other Diseases: Down’s Syndrome.- 26 The Role of Free Radical Reactions in Photobiology.- VII Defence Against Free Radical Reactions.- 1 Minimizing Exposure.- 2 Antioxidants.- 3 Summary.- Epilogue.- References.