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Whatever its final readership and impact, we, the Editors, feel this book is im­ portant. It addresses the realisation that there is a deep and abiding synergy, albeit one only now being properly explored and exploited, between immunol­ ogy and computational science. This area of intersection we christen in silico immunology. Immunology is an inspiration for computational scientists seek­ ing practical and philosophical metaphors for their work; but, at the same time, it is itself a biologi...