Laboratory Animal Anaesthesia

Laboratory Animal Anaesthesia

by Paul Flecknell
Laboratory Animal Anaesthesia

Laboratory Animal Anaesthesia

by Paul Flecknell

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Overview

Providing appropriate and effective anaesthesia and analgesia for laboratory animals is an essential part of experimental design. It can also be a major factor in improving animal welfare, by implementing Russell and Burch's concept of "refinement."

The additions and amendments to this new edition reflect developments in anaesthetic practice and changes in our attitudes towards laboratory animal welfare. Standards of anaesthesia for laboratory animals have increased greatly since the publication of the second edition, and the use of technically demanding procedures have become much more widespread. This new edition attempts to balance the need for additional information in these areas with the main goal of the first edition: the provision of an introductory text for new investigators.

Provides clear, concise and practical advice on laboratory animal anaesthesia

Includes new information on anaesthesia and analgesia, and has an extensively revised and updated bibliography

Presents a balanced consideration of the needs of scientific research and the welfare of laboratory animals

Written by a veterinary anaesthetist and scientist with over 30 years experience in the field, and who is actively engaged in research in this area

Offers rapid, easily accessed information using tabulated summaries

Provides those with limited experience of anaesthesia with the information they need to carry out procedures effectively, safely, and humanely

Provides sufficient depth for the more experienced anaesthetist moving to this field


Product Details

ISBN-13: 9780128005781
Publisher: Elsevier Science
Publication date: 09/21/2015
Sold by: Barnes & Noble
Format: eBook
Pages: 350
File size: 8 MB

About the Author

Paul Flecknell is a veterinarian with over 35 years of experience working with laboratory animals. He is a Diplomate of the European Colleges of Veterinary Anaesthesia and Analgesia and Laboratory Animal Medicine and an honorary Diplomate of the American College of Laboratory Animal Medicine. He has PhD in physiology, and is currently Professor of Laboratory Animal Science in the Institute of Neuroscience at Newcastle University. His main research interests are anaesthesia and analgesia of all species of animals and in particular the development of methods of pain assessment. He is the head of the Pain and Animal Welfare Science (PAWS) group at Newcastle. The group’s current research work is focussed on novel methods of “cage-side” assessment of pain, particularly using “pain faces” and developing methods of measurement of affective state in rodents.

Table of Contents

Preface vii

Preface to the Second Edition ix

Preface to the First Edition xi

Glossary xiii

List of Tables xv

List of Figures xix

Acknowledgements xxi

Introduction xxiii

1 Preparing for Anaesthesia 1

Anaesthetic equipment and anaesthetic drugs 1

Other equipment 8

Personnel 14

The animal 15

2 Anaesthesia 19

General anaesthesia 20

3 Anaesthetic Management 79

Pre-operative preparations 79

Monitoring anaesthesia 81

Anaesthetic problems and emergencies 95

4 Special Techniques 109

Use of neuromuscular blocking agents 109

Controlled ventilation 113

Long-term anaesthesia 119

Anaesthesia of pregnant animals 131

Anaesthesia of neonates 134

Anaesthesia for imaging 135

5 Analgesia and Post-operative Care 139

The recovery room environment 140

Problems during the recovery period 142

Management of post-operative pain 147

Pain assessment 153

Pain relief 160

Conclusions 179

6 Anaesthesia of Common Laboratory Species: Special Considerations 181

Small rodents 183

Rabbits 204

Cats 212

Dogs 217

Ferrets 221

Pigs 222

Sheep and goats 227

Primates 231

Other species 234

Bibliography 243

Appendix 1 Recommended Techniques and Physiological Data 275

Appendix 2 Estimation of Required Quantities of Volatile Anaesthetics and Anaesthetic Gases 281

Appendix 3 Examples of Dilutions of Anaesthetic Mixtures for Small Rodents 283

Appendix 4 Manufacturers of Equipment and Other Items Illustrated or Cited in the Text 287

Index 291

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