Molecular Biology and Brain Ischemia

by Koji Shimoji

Overview

The latest advances in molecular neurobiology have contributed significantly to understanding the pathophysiology of brain ischemia/hypoxia and have led to more effective measures to protect against ischemic brain damage. An especially important feature of this book is the new insight it provides into the molecular neurobiology of neurotransmission, the functional structures of glutaminergic receptors, the functional proteins of synapses, and synaptic plasticity. Recent progress is reported in elucidating the pathophysiological roles of NO, free radicals, and intracellular pH and calcium ions in brain ischemia/hypoxia, and a unique approach for protective and therapeutic measures against this condition is described. Molecular Neurobiology and Brain Ischemia will be of special interest to researchers and practitioners in neurobiology and related fields, including neurosurgeons,

Product Details

ISBN-13:	9784431684695
Publisher:	Springer Japan
Publication date:	03/09/2012
Edition description:	Softcover reprint of the original 1st ed. 1996
Pages:	164
Product dimensions:	6.10(w) x 9.25(h) x 0.01(d)

Table of Contents

Functional Proteins in the Presynaptic Terminal.- Molecular Structure and Physiological Function of the Glutamate Receptor Channel.- Metabotropic Glutamate Responses and the Intracellular Mechanisms.- Long-Term Potentiation and Drugs.- Analysis of Distributions of Nitric Oxide Synthase mRNAs in the Normal Rat Brain by In Situ Hybridization Hishemistry.- Calcium-Dependent Neuronal Cell Death.- Effects of Glutamate Agonists and Antagonists on Ischemic Damage of Hippocampal Neurons.- Changes in Intracellular Ca2+ and pH of Hippocampal Slices in Response to Ischemia In Vitro.- Role of Nitric Oxide in Ischemic Brain Damage.- Protective Effect of Brain Microinjury Against Brain Ischemia.