Target Identification and Validation in Drug Discovery: Methods and Protocols
This third edition book explores breakthrough techniques in the field of drug target identification and validation. With technologies and methodologies ranging from target identification to the analysis of clinical samples, as well as newer areas like artificial intelligence and machine learning applications, the book will aid decision-makers in drug development by offering a succinct overview of the available technologies for portfolio management. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory prools, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and up-to-date, Target Identification and Validation in Drug Discovery: Methods and Prools, Third Edition will help a diverse audience of scientists find valuable insights to address their drug development inquiries.

1113472456
Target Identification and Validation in Drug Discovery: Methods and Protocols
This third edition book explores breakthrough techniques in the field of drug target identification and validation. With technologies and methodologies ranging from target identification to the analysis of clinical samples, as well as newer areas like artificial intelligence and machine learning applications, the book will aid decision-makers in drug development by offering a succinct overview of the available technologies for portfolio management. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory prools, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and up-to-date, Target Identification and Validation in Drug Discovery: Methods and Prools, Third Edition will help a diverse audience of scientists find valuable insights to address their drug development inquiries.

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Target Identification and Validation in Drug Discovery: Methods and Protocols

Target Identification and Validation in Drug Discovery: Methods and Protocols

Target Identification and Validation in Drug Discovery: Methods and Protocols
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Target Identification and Validation in Drug Discovery: Methods and Protocols

Target Identification and Validation in Drug Discovery: Methods and Protocols

Overview

This third edition book explores breakthrough techniques in the field of drug target identification and validation. With technologies and methodologies ranging from target identification to the analysis of clinical samples, as well as newer areas like artificial intelligence and machine learning applications, the book will aid decision-makers in drug development by offering a succinct overview of the available technologies for portfolio management. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory prools, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and up-to-date, Target Identification and Validation in Drug Discovery: Methods and Prools, Third Edition will help a diverse audience of scientists find valuable insights to address their drug development inquiries.

Product Details

ISBN-13: 9781071644171
Publisher: Springer US
Publication date: 04/01/2025
Series: Methods in Molecular Biology , #2905
Edition description: Third Edition 2025
Pages: 270
Product dimensions: 7.01(w) x 10.00(h) x (d)

Table of Contents

A Systemic View of Target Identification: Modeling the Warburg Effect.- Structural Biology for Target Identification and Validation.- Design and Preliminary Screen of Antisense Oligonucleotides.- Integration of RNAi and Small Molecule Library Screens to Identify Targets for Drug Discovery.- A Robust siRNA Screening Approach with Optimized Conditions for Large-Scale Transfection in Multiple Human Cancer Cell Lines.- Functional Lineage Tracing Using CaTCH.- Exploring the Perturbation of Biological Processes Caused by Gene Upregulation Using Knock-In Transfection, Transcriptomics, and Bioinformatics Analysis.- A Reverse Engineering Approach to Optimize Chemical Synergy Between Target and Phenotype: Bridging the Cancer and Malaria Indications.- High-Content Imaging-Based Screening for Anti-Cancer Compounds in Zebrafish Xenografts.- Identification of Protein Kinase Drug Targets Using Activity Estimation in Clinical Phosphoproteomics.- Click Chemistry for Target Engagement Studies.- The Power of Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS) in Structural Biology and Protein-Ligand Interactions.- Advancing Target Validation and Ligandability Assessment: Fragment Screening via 19F NMR Spectroscopy.- In Vivo Micro-CT Imaging for Quantitative Longitudinal Assessment of Pulmonary Diseases in Small Animals.- The NeuroSphere Assay Applied to Neural Stem Cells and Cancer Stem Cells.- High Efficiency Lentiviral Transduction of Colon Organoids Using Reversible 2D/3D Culture Techniques.- 3D Tumor Model to Study Immune Cell Infiltration.

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