Viral Replication Complexes: Structures, Functions, Applications and Inhibitors

Viral Replication Complexes: Structures, Functions, Applications and Inhibitors

by MDPI AG

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Overview

Viral Replication Complexes: Structures, Functions, Applications and Inhibitors by MDPI AG

Viruses are obligate intracellular parasites that need to co-opt a living cell’s machinery for replication. At the heart of the viral replication machinery are the nucleic acid polymerases, which are responsible for efficiently copying the viral genome. This process must often be coordinated with other viral processes, including protein translation and viral packaging. The polymerases and other components of the replication machinery may serve as potential anti-viral targets.

Section 1 of this book is devoted to the basic structure–function relationships of viral nucleic acid polymerases and related proteins. Section 2 then discusses how interactions between the viral polymerase and viral nucleic acids and other proteins help to coordinate nucleic acid synthesis and other important viral processes. Section 3 builds on this discussion by including the roles of host proteins in these processes. Many viruses also co-opt host lipid membranes to provide more conducive environments for RNA synthesis and virus replication, which is discussed in Section 4. Finally, many of the processes discussed in the preceding sections are potential antiviral drug targets, which is discussed in Section 5.

Product Details

ISBN-13: 9783038421672
Publisher: MDPI AG
Publication date: 07/15/2016
Pages: 444
Product dimensions: 6.69(w) x 9.61(h) x 1.38(d)

Table of Contents

Chapter 1: Molecular Perspectives on Virus Replication Proteins
RNA-Dependent RNA Polymerases of Picornaviruses: From the Structure to
Regulatory Mechanisms
Using the Hepatitis C Virus RNA-Dependent RNA Polymerase as a Model to
Understand Viral Polymerase Structure, Function and Dynamics
Nucleobase but not Sugar Fidelity is Maintained in the Sabin I RNA-Dependent
RNA Polymerase
Conformational Ensemble of the Poliovirus 3CD Precursor Observed by MD
Simulations and Confirmed by SAXS: A Strategy to Expand the Viral Proteome?

Chapter 2: Coordinated Interactions of Viral Proteins and Nucleic
Acids
Coordinated DNA Replication by the Bacteriophage T4 Replisome
HIV Rev Assembly on the Rev Response Element (RRE): A Structural Perspective
Translational Control of the HIV Unspliced Genomic RNA
Flaviviral Replication Complex: Coordination between RNA Synthesis and 5'-
RNA Capping
Modes of Human T Cell Leukemia Virus Type 1 Transmission,
Replication and Persistence

Chapter 3: Interplay Between Virus and Host in Virus Replication
HIV-1 Replication and the Cellular Eukaryotic Translation Apparatus
Reprinted from: Viruses 2015, 7(1), 199-218
APOBEC3 Interference during Replication of Viral Genomes
Hydrogen Peroxide Induce Human Cytomegalovirus Replication through the
Activation of p38-MAPK Signaling Pathway
Both ERK1 and ERK2 Are Required for Enterovirus 71 (EV71) Efficient Replication

Chapter 4: Virus Replication Organelles
The Virus-Host Interplay: Biogenesis of +RNA Replication Complexes
The Role of Electron Microscopy in Studying the Continuum of Changes in
Membranous Structures during Poliovirus Infection
Amino Terminal Region of Dengue Virus NS4A Cytosolic Domain Binds to
Highly Curved Liposomes

Chapter 5: Antiviral Drugs
Anti-HBV Drugs: Progress, Unmet Needs, and New Hope
Replication and Inhibitors of Enteroviruses and Parechoviruses

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