A Pharmacology Primer: Theory, Applications, and Methods

by Terry P. Kenakin

Overview

The Second Edition will continue this tradition of better preparing researchers in the basics of pharmacology. In addition, new human interest material including historical facts in pharmacology will be added. A new section on therapeutics will help readers identify with diseases and drug treatments.

• Over 30 new figures and tables
• More human interest information to provide readers with historical facts on pharmacology research
• New section on therapeutics to help identify diseaes and drug treatments
• New section on new biological concepts relevant to pharmacological research (i.e., systems biology)
• New study sections organized with ASPET and other international pharmacology organizations
• New coverage of pharmacokinetics and drug disposition

Product Details

ISBN-13:	9780080465302
Publisher:	Elsevier Science
Publication date:	10/30/2006
Series:	A Pharmacology Primer Series
Sold by:	Barnes & Noble
Format:	eBook
Pages:	318
File size:	22 MB
Note:	This product may take a few minutes to download.

About the Author

Dr. Terry Kenakin is Professor of Pharmacology at the University of North Carolina School of Medicine. Prior to this, he spent 7 years in drug discovery at Burroughs-Wellcome. He then moved to GlaxoSmithKline for 25 years. Dr. Kenakin has written 11 books on Pharmacology, is the Editor in Chief of the Journal of Receptors and Signal Transduction, is on numerous Editorial Boards. He is the Editor-in-Chief of Comprehensive Pharmacology (Elsevier, 2022). He is the recipient of the 2008 Poulsson Medal for Pharmacology awarded by the Norwegian Society of Pharmacology for achievements in basic and clinical pharmacology and toxicology. He has also been awarded the 2011 Ariens Award from the Dutch Pharmacological Society and the 2014 Gaddum Memorial Award from the British Pharmacological Society, and the 2020 Goodman and Gilman Award in Receptor Pharmacology from ASPET.

Table of Contents

Chapter 1: What Is Pharmacology?

Chapter 2: How Different Tissues Process Drug Response

Chapter 3: Drug-Receptor Theory

Chapter 4: Pharmacological Assay Formats: Binding

Chapter 5: Agonists: The Measurement of Affinity and Efficacy in Functional Assays

Chapter 6: Orthosteric Drug Antagonism

Chapter 7: Allosteric Drug Antagonism

Chapter 8: The Process of Drug Discovery

Chapter 9: Target- and System-based Strategies for Drug Discovery

Chapter 10: “Hit” to Drug: Lead Optimization

Chapter 11: Statistics and Experimental Design

Chapter 12: Selected Pharmacological Methods

Glossary of Pharmacological Terms

Appendices

Index