This book provides updated knowledge on the basic features and mechanisms of cellular aging established since its first manifestation at cellular level 40 years ago. Contributions of genetic and environmental factors, failure of genetic and cellular repair mechanisms, and the epigenetic modifications determine the final lifespan of cells. This book also provides an understanding on how aging mechanisms in mice, a most frequently used model, differ with that of humans who receive better tumor surveillance because of stringent controls on aging mechanisms. It also appraises the use of modern technology for aging studies and its intervention. This book serves as an excellent reading on cellular aging for undergraduate students, researchers and experts of this area.
Table of ContentsContributors. Preface; S.C. Kaul, R. Wadhwa. 1. Aging outside the body: usefulness of the Hayflick system; S.I.S. Rattan. 2. Genetics of cellular aging; O.M. Pereira-Smith, P. Rookard, J. Echigo, J.R. Smith. 3. Aging of fibroblasts; D. Kletsas. 4. Aging of endothelial cells; T. Kurnazaki. 5. In vitro senescence of human osteoblasts; M. Kassem, K. Stenderup, J. Justesen, M. Kveiborg. 6. T cell immunosenescence; G. Pawelec. 7. Aging of premature-aging syndrome cells; J.O. Nehlin. 8. The p53 pathway, cancer and aging; A.W. Braithwaite, S.J. Edwards. 9. Regulation of cellular senescence by the retinoblastoma pathway; T.M. Becker, H. Rizos. 10. Telomeres and cellular aging; C.D. Toouli, R.R. Reddel. 11. Molecular chaperones and cellular aging; G. Morrow, R.M. Tanguay. 12. Cellular senescence pathways in mouse and human; R. Wadhwa, Md. Kamrul Hasan, S.C. Kaul. 13. Therapeutic induction of cellular senescence: nuclear matrix in senescence; D. Ayusawa. 14. Use of hammerhead ribozymes for aging and cancer; H. Minoshima, E. Suyama, R. Wadhwa, K. Taira.