Amyotrophic Lateral Sclerosis: Pathogenesis and Therapeutic Directions

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes a progressive loss of motor neurons which controls voluntary muscles. It is a common motor neuron disease, which has symptoms like stiff muscles, muscle twitches, gradually growing weakness and muscle wasting. ALS leads to paralysis and early death, due to respiratory failure. There is no known cause and currently no treatment for ALS. However, life expectancy can be increased by two to three months by using a me...