Annual Reports in Combinatorial Chemistry and Molecular Diversity

Annual Reports in Combinatorial Chemistry and Molecular Diversity

Paperback(Softcover reprint of the original 1st ed. 1999)

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Overview

Annual Reports in Combinatorial Chemistry and Molecular Diversity by M.R. Pavia

Combinatorial chemistry and molecular diversity approaches to scientific and novel product R & D have exploded in the 1990s. For example, in the preparation of drug candidates, the automated, permutational, and combinatorial use of chemical building blocks now allows the generation and screening of unprecedented numbers of compounds. Drug discovery - better, faster, cheaper? Indeed more compounds have been made and screened in the 1990s than in the last hundred years of pharmaceutical research.
The second volume in this series includes contributions on methods, solid phases, purification, analysis, carbohydrates, patent strategies and tactics, diversity profiling and combinatorial series design, and finishes with a survey of chemical libraries yielding biologically active agents and a compendium of solid phase chemistry publications. Each contribution is prepared by a recognized expert resulting in a high quality account of the recent advances in the field.

Product Details

ISBN-13: 9789048152278
Publisher: Springer Netherlands
Publication date: 12/07/2010
Series: Annual Reports in Combinatorial Chemistry & Molecular Diversity , #2
Edition description: Softcover reprint of the original 1st ed. 1999
Pages: 174
Product dimensions: 7.01(w) x 10.00(h) x 0.01(d)

Table of Contents

Preface. Introduction; M.R. Pavia, W.H. Moos. Solution-phase combinatorial chemistry; D.M. Coe, C. Storer. New developments in solid phase synthesis; I. Sucholeiki. Recent advances in solid phase synthesis; S.E. Hall. Purification of combinatorial libraries; H.N. Weller. Analytical methods for quality control of combinatorial libraries; W.L. Fitch. Accessing Carbohydrate-based combinatorial libraries through solid phase and solution phase approaches; M.J. Sofia. Patent Strategies in molecular diversity; G.D. Green. Patent tactics in molecular diversity: Things that get around, come around; K. Bozicevic. Advances in diversity profiling and combinatorial series design; D.K. Agrafiotis, et al. Comprehensive survey of chemical libraries yielding enzyme inhibitors, receptor agonists and antagonists, and other biologically active agents: 1992 through 1997; R.E. Dolle. Compendium of solid phase chemistry publications; I.W. James. Author Index. Subject Index.

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