Beyond nihilism: Imperfection on the move

How to escape from nihilistic despair: the loss of faith in absolutes of God, the True, the Good and the Beautiful, or in our ability to achieve them? Following Nietzsche, we might be glad to be rid of them, rejoicing in ongoing effort to learn and create, even if, or perhaps because, we never achieve perfection. In other words: imperfection on the move. How does imperfection on the move work? What does it mean for religion? For knowledge and truth, for ethics and morality? And for happines...