Biochemistry of Brain

by Sudhir Kumar (Editor)

Overview

Biochemistry of Brain is a collection of articles dealing with the developments in the biochemistry of the brain. This book gives a comprehensive and critical discussion of important developments in studies concerning the above subject. This text discusses the structure, function, and metabolism of glycosphingolipids, which are related to the study of sphingolipid storage diseases. Inborn defects of metabolism are found in Gaucher's and Fabry's disease, which are characterized by lipid accumulation in the brain. Another paper reviews the chemical and genetics of critically lysosomal hydrolase deficiencies that can cause the storage of sphingolipids. This book then explains the role of myelin basic protein in lipids in vivo that the weak bonding of the protein is not a major component of myelin stability. Another paper discusses the procedures for isolating subfractions of myelin and myelin-related membranes, with some attention given on the alterations in the subfractionation of myelin in pathological hypomyelinating and demyelinating conditions. Another article discusses the biochemical and enzymatic composition of lysosomes and the biosynthesis, intracellular transport, storage, and the degradation of lysosomal constituents. This collection of papers will benefit scientists doing research in microbiology, microchemistry, molecular genetics, and neurochemistry.

Product Details

ISBN-13:	9781483153599
Publisher:	Pergamon
Publication date:	10/22/2013
Sold by:	Barnes & Noble
Format:	eBook
Pages:	634
File size:	13 MB
Note:	This product may take a few minutes to download.

About the Author

Dr. Sudhir Kumar is currently working as a Professor and Head of the Department of Biotechnology and Bioinformatics at Jaypee University of Information Technology, Waknaghat, Solan, Himachal Pradesh, India. He completed his Bachelor’s and Master’s from Panjab University, Chandigarh. He then joined Thapar University, Patiala as a CSIR Fellow and completed his doctorate in Biotechnology. During Ph.D. his work was focused on bioremediation and biofuel production. He joined Department of Chemical and Biological Engineering, South Dakota School of Mines and Technology, USA as a postdoctoral research associate. His research work is focused on biofuels production from food and agricultural waste, bioleaching of precious metals from e-waste and industrial enzymes. He is actively involved in training and educating the students and general public to promote technology extension in the area of biogas from municipal solid waste and agricultural residues. He has worked on various sponsored research projects and at present is working as a PI in three projects with one of the projects focused on Biohydrogen production from Pine needles.

Table of Contents

Chapter 1: STRUCTURE, FUNCTION AND METABOLISM OF GLYCOSPHINGOLIPIDS Chapter 2: METABOLIC DISORDERS IN SPHINGOLIPIDOSES Chapter 3: MYELIN BASIC PROTEIN: WHAT DOES IT DO? Chapter 4: THE BIOCHEMICAL AND MORPHOLOGICAL HETEROGENEITY OF MYELIN AND MYELIN-RELATED MEMBRANES Chapter 5: FOLATE METABOLISM IN BRAIN Chapter 6: VITAMIN B12 AND THE NERVOUS SYSTEM Chapter 7: BRAIN BIOGENIC AMINES IN MENTAL DYSFUNCTIONS ATTRIBUTABLE TO THYROID HORMONE ABNORMALITIES Chapter 8: BRAIN SPECIFIC PROTEINS Chapter 9: BRAIN NUCLEIC ACIDS Chapter 10: FREE NUCLEOTIDES AND NUCLEIC ACIDS DURING BRAIN DEVELOPMENT Chapter 11: TRANSFER RNA's IN BRAIN Chapter 12: MOLECULAR BIOLOGICAL ASPECTS OF DEGENERATION OF THE NERVOUS SYSTEM CAUSED BY AGING AND SENSORY DEPRIVATION Chapter 13: NUTRITION AND AMINO ACID IMBALANCE AS FACTORS INFLUENCING BRAIN DEVELOPMENT Chapter 14: BRAIN AMINO ACIDS Chapter 15: MOLECULAR NEUROBIOLOGY OF MEMORY Chapter 16: NEURAL TISSUE CULTURE: A BIOCHEMICAL TOOL Chapter 17: NEUROTOXIC EFFECTS OF HEAVY METALS AND METALLOIDS Chapter 18: AMINOTRANSFERASES AND THE DEVELOPING BRAIN Chapter 19: ROLE OF CYCLIC AMP IN DEVELOPING BRAIN Chapter 20: PROTEIN PHOSPHORYLATION-INVOLVEMENT IN BRAIN FUNCTION Chapter 21: NERVE GROWTH FACTOR Chapter 22: BRAIN LYSOSOMES AND LYSOSOMAL ENZYMES Chapter 23: SPECIFICITY OF CNS MYELIN PROTEOLIPID PROTEIN AND BASIC PROTEIN: Preparation of antibodies specific to myelin proteolipid protein and basic protein and the immunohistochemical localization of these antigens exclusively to myelin and oligodendrocytes INDEX