Cholesterol: Its Functions and Metabolism in Biology and Medicine / Edition 1

by Robert Bittman

Overview

Experts investigate the biochemical and biomedical aspects of cholesterol, addressing its metabolism in normal and disease states. They discuss a broad range of topics, including key steps in the cholesterol biosynthetic pathway, and the role of cholesterol in cancer, atherosclerosis, and diseases of the nervous system. The book's comprehensive coverage also includes the pathological consequences and potential therapies for various disease states, and the development of new anti-atherogenic drugs.

Product Details

ISBN-13:	9781461377078
Publisher:	Springer US
Publication date:	09/25/2012
Series:	Subcellular Biochemistry , #28
Edition description:	Softcover reprint of the original 1st ed. 1997
Pages:	548
Product dimensions:	6.10(w) x 9.25(h) x 0.05(d)

About the Author

Bittman, Robert (Queens Coll)

The contributors represent the specialties of clinical chemistry and biochemistry, biopharmacology, clinical genetics, physiology, and molecular biology. Most come from universities and research institutes in nine countries, including the U.S., the Netherlands, Sweden, and Japan. Institutions prominently represented include NIH, UCLA, Tufts, Texas Tech, Allegheny Univ, and UMD-New Jersey Medical School.

Table of Contents

1 Signaling Molecules Derived from the Cholesterol Biosynthetic Pathway.- 2 Coordinate Regulation of Cholesterol 7'-Hydroxylase and HMG-CoA Reductase in the Liver.- 3 Polyprenyl Diphosphate Synthases.- 4 Antifungal Sterol Biosynthesis Inhibitors.- 5 The Smith-Lemli-Opitz Syndrome: A Potentially Fatal Birth Defect Caused by a Block in the Last Enzymatic Step in Cholesterol Biosynthesis.- 6 Has Nature Designed the Cholesterol Side Chain for Optimal Interaction with Phospholipids?.- 7 Cholesterol and Myelin.- 8 Regulation of Mihondrial Cholesterol Metabolism.- 9 Lipoproteins and Cellular Cholesterol Homeostasis.- 10 Cholesterol-Sphingomyelin Interactions in Cells—Effects on Lipid Metabolism.- 11 Mechanisms and (Patho)Physiological Significance of Biliary Cholesterol Secretion.- 12 Cholesterol Deposition in Atherosclerotic Lesions.- 13 Cholesterol Metabolism and Tumor Cell Proliferation.- 14 Biological Implications of the Niemann-Pick C Mutation.- 15 Sitosterolemia.- 16 Cholesterol Cyhemistry in Cell Biology and Disease.- 17 Approaches for the Design of Novel Anti-Atherogenic Compounds.

Editorial Reviews

‘An excellent and up-to-date overview...A useful volume for libraries, investigators, or graduate students.'
Inform, September 1998

From the Publisher