CONFORMATIONAL PROTEOMICS OF MACROMOLECULAR ARCHITECTURE: APPROACHING THE STRUCTURE OF LARGE MOLECULAR ASSEMBLIES AND THEIR MECHANISMS OF ACTION (WITH CD-ROM)

Biological processes involving large macromolecular assemblies are thought to be a dynamic consequence of cooperativity and metastability. The folding of a peptide chain creates local environments from which “activity” can emerge. In the same way, the assembly of large molecular complexes creates dynamic features that would only be feasible in a large construct. The biological implications of such adaptation are explored as it applies to the static quasisymmetry situations, as well as to th...