Crossover Designs: Testing, Estimation, and Sample Size

A comprehensive and practical resource for analyses of crossover designs

For ethical reasons, it is vital to keep the number of patients in a clinical trial as low as possible. As evidenced by extensive research publications, crossover design can be a useful and powerful tool to reduce the number of patients needed for a parallel group design in studying treatments for non-curable chronic diseases.

This book introduces commonly-used and well-established statistical tests and estimators in ...