Cytochrome P-450: Structure, Mechanism, and Biochemistry

Major advances have been made in recent years in clarifying the molecular properties of the cyhrome P-450 system. These advances stem, in practical terms, from the generally recognized importance of cyhrome P-450 in the metabolism of drugs and in the bioactivation of xenobiotics to toxic products. The fascinating multiplicity and differential regulation of cyhrome P-450 isozymes, and their ability to catalyze extraordinarily difficult chemical transformations, have independently drawn many ...