Diabetic Renal-Retinal Syndrome: Pathogenesis and Management Update 2002 / Edition 1

by E.A. Friedman, Francis A. L'Esperance Jr.

Overview

Fresh insights into the pathogenic mechanisms by which hyperglycemia induces tissue and organ injurt are the basis for rapidly evolving promising therapies in diabetes. Especially promising as targets for intervention are products of oxidative stress, including kinins and growth factors. Improving results of renal replacement regimes now incorporating pancreatic islet transplants are able to delay and prevent end-organ damage in diabetic individuals. The evolving story of the taming of diabetes is of direct concern to nephrologists, endocrinologists, ophthalmologists, primary care physicians and medical students.

Product Details

ISBN-13:	9789401039307
Publisher:	Springer Netherlands
Publication date:	10/04/2012
Edition description:	2002
Pages:	246
Product dimensions:	6.10(w) x 9.25(h) x 0.02(d)

About the Author

Friedman, Eli A., MD (SUNY at Brooklyn); L'Esperance, Francis A., Jr., MD (Columbia Univ Coll of Physicians and Surgeons)

Table of Contents

1. Effect of Aminoguanidine on Induced-diabetic Rabbits and Diabetic Patients with ESRD.- 2. Impact of Nutrition in Uremic Diabetics.- 3. New Insights into the Molecular Mechanisms of Vascular Permeability in Diabetes.- 4. Apoptosis and Neurodegeneration in Diabetes: Lessons From the Retina.- 5. Diabetic Macular Edema.- 6. Diabetic Vitrectomy Update.- 7. Medical Approaches to Preventing Vision Loss from Diabetic Retinopathy.- 8. Ocular Findings at Onset of Uremia.- 9. Proliferative Diabetic Retinopathy: Current Treatment Strategies for Progression.- 10. Microalbuminuria in Perspectives.- 11. Which Comes First: Renal Injury or Microalbuminuria?.- 12. Prevention, Diagnosis and Management of Heart Disease in Patients with Renal Failure.- 13. Reducing Mortality for Diabetes Patients on Hemodialysis.- 14. Long-Term Perspective on Utility of Peritoneal Dialysis in Diabetes.- 15. Complications of Post-transplant Diabetes.- 16. Prevalent US Transplant Center Policies Towards Pancreas Transplantation for Patients with Type 2 Diabetes Mellitus.- 17. Pancreas Transplantation: Does It Have a Future?.- 18. Novel Applications for Recombinant Human Erythropoietin.- 19. Lessons Learned Since the Last Renal-Retinal Conference.

Editorial Reviews

The conference that generated the 20 studies is cited as November 1979, surely an error for 1997. The discussions incorporate new evidence that the progress of diabetic complications affecting the eye can be can be slowed with intensive metabolic regulation and the reduction of hypertensive blood pressure, and the potential shown by research in advanced glycated endproducts for interdicting such complications by blocking molecular perturbations induced by hyperglycemia. The topics include epidemiology and impact, stages of diabetic nephropathy, three decades of experience with dialysis in diabetic patients, the natural history and classification of diabetic retinopathy, the surgical management of proliferative diabetic retinopathy, the xenotransplantion of encapsulated porcine islets, generating non-immunogenic islet cells using genetic engineering, and discontinuing dialysis. Annotation c. by Book News, Inc., Portland, Or.

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