Essentials of Pathophysiology

by Carol Porth, Kathryn J. Gaspard Ph.D., Kim A. Noble Ph.D.

Overview

Looking for a text that delivers concept-based information about disease processes and altered health states? Essentials of Pathophysiology is the right text for you! Written by a noted expert in pathophysiology, this abundantly illustrated and accessible resource is filled with learning tools that highlight the ideas most vital to your understanding. Consistent with the author's philosophy, Essentials of Pathophysiology relates normal body functioning to the physiologic changes involved in pathogenesis and those that result from disease.

Product Details

ISBN-13:	9781451116380
Publisher:	Lippincott Williams & Wilkins
Publication date:	12/01/2010
Edition description:	Older Edition
Product dimensions:	8.40(w) x 10.90(h) x 2.20(d)

Table of Contents

Unit 1	Mechanisms of Disease
1	Cell Structure and Function	1
	Functional Components of the Cell	2
	Cell Metabolism and Energy Sources	7
	Cell Membrane Transport, Signal Transduction, and Generation of Membrane Potentials	9
	Body Tissues	14
2	Tissue Adaptation and Injury	24
	Cellular Adaptation	24
	Cell Injury and Death	27
3	Genetic Control of Cell Function	36
	Genetic Control of Cell Function	36
	Chromosomes	41
	Patterns of Inheritance	44
	Gene Mapping and Technology	46
4	Genetic and Congenital Disorders	50
	Genetic and Chromosomal Disorders	50
	Disorders Due to Environmental Influences	58
5	Alterations in Cell Growth and Replication: Neoplasia	64
	Concepts of Cell Growth	64
	Characteristics of Benign and Malignant Neoplasms	67
	Carcinogenesis and Causes of Cancer	72
	Clinical Features	77
	Childhood Cancers	81
6	Alterations in Fluids, Electrolytes, and Acid-Base Balance	84
	Composition and Compartmental Distribution of Body Fluids	84
	Sodium and Water Balance	90
	Potassium Balance	99
	Calcium and Magnesium Balance	103
	Acid-Base Balance	108
Unit 2	Alterations in Body Defenses
7	Stress and Adaptation	121
	Homeostasis	122
	Stress	123
	Disorders of the Stress Response	128
8	The Immune Response	134
	The Immune System	134
	Developmental Aspects of the Immune System	148
9	Inflammation, Tissue Repair, and Fever	150
	The Inflammatory Response	150
	Tissue Repair and Wound Healing	157
	Temperature Regulation and Fever	161
10	Alterations in the Immune Response	168
	Allergic and Hypersensitivity Disorders	168
	Transplantation Immunopathology	174
	Autoimmune Disorders	175
	Immunodeficiency Disorders	178
Unit 3	Alterations in the Hematologic System
11	Alterations in White Blood Cells	191
	Hematopoietic and Lymphoid Tissue	191
	Non-neoplastic Disorders of White Blood Cells	194
	Neoplastic Disorders of Hematopoietic and Lymphoid Origin	197
12	Alterations in Hemostasis and Blood Coagulation	205
	Mechanisms of Hemostasis	205
	Hypercoagulability States	209
	Bleeding Disorders	210
13	Alterations in Red Blood Cells	216
	The Red Blood Cell	216
	Anemia	220
	Polycythemia	227
	Age-Related Changes in Red Blood Cells	227
Unit 4	Alterations in the Cardiovascular System
14	Structure and Function of the Cardiovascular System	231
	Organization of the Circulatory System	232
	Principles of Blood Flow	233
	The Heart as a Pump	236
	Blood Vessels and the Peripheral Circulation	246
	Neural Control of Circulatory Function	251
15	Alterations in Blood Flow	254
	Disorders of the Arterial Circulation	254
	Disorders of the Venous Circulation	266
	Disorders of Blood Flow Caused by Extravascular Forces	269
16	Alterations in Blood Pressure	274
	Control of Blood Pressure	274
	Hypertension	279
	Orthostatic Hypotension	287
17	Alterations in Cardiac Function	291
	Disorders of the Pericardium	291
	Coronary Heart Disease	294
	Myocardial and Endocardial Disease	302
	Valvular Heart Disease	308
	Heart Disease in Infants and Children	312
18	Heart Failure and Circulatory Shock	320
	Heart Failure	320
	Circulatory Failure (Shock)	330
	Heart Failure in Children and the Elderly	336
Unit 5	Alterations in the Respiratory System
19	Structure and Function of the Respiratory System	339
	Structural Organization of the Respiratory System	340
	Exchange of Gases Between the Atmosphere and the Lungs	344
	Exchange and Transport of Gases	351
	Control of Breathing	356
20	Alterations in Respiratory Function: Infectious Disorders and Neoplasia	359
	Respiratory Tract Infections	359
	Cancer of the Lung	367
	Respiratory Disorders in Infants and Children	369
21	Alterations in Respiratory Function: Disorders of Gas Exchange	376
	Disorders of Lung Inflation	376
	Obstructive Airway Disorders	380
	Interstitial Lung Diseases	390
	Pulmonary Vascular Disorders	392
	Respiratory Failure	395
Unit 6	Alterations in the Urinary System
22	Control of Kidney Function	401
	Kidney Structure and Function	402
	Tests of Renal Function	412
23	Alterations in Renal Function	415
	Congenital and Hereditary Disorders of the Kidney	415
	Obstructive Disorders	417
	Urinary Tract Infections	421
	Disorders of Glomerular Function	425
	Tubulointerstitial Disorders	429
	Neoplasms	430
24	Renal Failure	433
	Acute Renal Failure	433
	Chronic Renal Failure	436
	Renal Failure in Children and Elderly Persons	443
25	Alterations in Urine Elimination	446
	Control of Urine Elimination	446
	Alterations in Bladder Function	449
	Cancer of the Bladder	456
Unit 7	Alterations in the Gastrointestinal System
26	Structure and Function of the Gastrointestinal System	459
	Structure and Organization of the Gastrointestinal Tract	460
	Innervation and Motility	463
	Hormonal and Secretory Function	466
	Digestion and Absorption	468
	Anorexia, Nausea, and Vomiting	471
27	Alterations in Gastrointestinal Function	473
	Disorders of the Esophagus	473
	Disorders of the Stomach	476
	Disorders of the Small and Large Intestines	480
28	Alterations in Hepatobiliary Function	494
	The Liver and Hepatobiliary System	494
	Disorders of the Liver	500
	Disorders of the Gallbladder and Extrahepatic Bile Ducts	510
	Disorders of the Exocrine Pancreas	513
29	Alterations in Body Nutrition	517
	Regulation of Food Intake and Energy Metabolism	517
	Overnutrition and Obesity	521
	Undernutrition	524
Unit 8	Alterations in the Endocrine System
30	Organization and Control of the Endocrine System	529
	The Endocrine System	529
31	Alterations in Pituitary, Thyroid, Parathyroid, and Adrenal Function	538
	General Aspects of Altered Endocrine Function	538
	Pituitary and Growth Hormone Disorders	539
	Thyroid Disorders	545
	Parathyroid Hormone Disorders	551
	Disorders of Adrenal Cortical Function	552
32	Diabetes Mellitus	560
	Energy Metabolism	560
	Diabetes Mellitus	565
Unit 9	Alterations in the Male and Female Reproductive Systems
33	Alterations in the Male Reproductive System	581
	Physiologic Basis of Male Reproductive Function	581
	Disorders of the Penis, the Scrotum and Testes, and the Prostate	587
	Disorders in Childhood and Aging Changes	597
34	Alterations in the Female Reproductive System	602
	Structure and Function of the Female Reproductive System	602
	Disorders of the Female Reproductive Organs	607
	Menstrual Disorders	619
	Disorders of the Breast	622
35	Sexually Transmitted Diseases	627
	Infections of the External Genitalia	627
	Vaginal Infections	630
	Vaginal-Urogenital-Systemic Infections	632
Unit 10	Alterations in the Nervous System
36	Organization and Control of the Nervous System	637
	Nervous Tissue Cells	637
	Nerve Cell Communication	641
	Development and Organization of the Nervous System	644
	The Spinal Cord and Brain	651
	The Autonomic Nervous System	660
37	Alterations in Brain Function	667
	Brain Injury	668
	Cerebrovascular Disease	679
	Infections and Neoplasms	685
	Seizure Disorders	688
	Dementias	691
38	Alterations in Neuromuscular Function	696
	The Organization and Control of Motor Function	696
	Skeletal Muscle and Peripheral Nerve Disorders	702
	Basal Ganglia and Cerebellum Disorders	709
	Upper and Lower Motoneuron Disorders	713
	Spinal Cord Injury	716
39	Pain	725
	Organization and Control of Somatosensory Function	725
	Pain	731
	Alterations in Pain Sensitivity and Special Types of Pain	739
	Headache	741
	Pain in Children and Older Adults	744
40	Alterations in Special Sensory Function	747
	The Eye and Disorders of Vision	747
	The Ear and Disorders of Auditory Function	763
	The Vestibular System and Maintenance of Equilibrium	772
Unit 11	Alterations in the Skeletal and Integumentary Systems
41	Structure and Function of the Skeletal System	779
	Characteristics of Skeletal Tissue	779
	Skeletal Structures	785
42	Alterations in the Skeletal System: Trauma, Infection, and Developmental Disorders	789
	Injury and Trauma of Musculoskeletal Structures	789
	Bone Infections	799
	Neoplasms	802
	Disorders of Skeletal Growth and Development in Children	805
43	Alterations in the Skeletal System: Metabolic and Rheumatoid Disorders	814
	Metabolic Bone Disease	814
	Rheumatic Disorders	820
	Rheumatic Diseases in Children and the Elderly	832
44	Alterations in Skin Function and Integrity	835
	Structure of the Skin	835
	Manifestations of Skin Disorders	839
	Skin Damage Caused by Ultraviolet Radiation	841
	Primary Disorders of the Skin	842
	Nevi and Skin Cancers	853
	Age-Related Skin Manifestations	857
	Glossary	863
Appendix A	Lab Values	873
Appendix B	Weblinks	875
	Index	879