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Extrasynaptic GABAA Receptors

By Adam C. Errington (Editor), Giuseppe Di Giovanni (Editor), Vincenzo Crunelli (Editor)
Hardcover
$109.99
By Adam C. Errington (Editor), Giuseppe Di Giovanni (Editor), Vincenzo Crunelli (Editor)
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GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasic” GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABA...

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