“The Family that Couldn’t Sleep is a riveting detective story that plumbs one of the deepest mysteries of biology. The story takes the reader from the torments of an Italian family cursed with sleeplessness to the mad cows of England (and, now, America), following an unlikely trail of misfolded proteins. D. T. Max unfolds his absorbing narrative with rare grace and makes the science sing.” –Michael Pollan, author of The Omnivore’s Dilemma and The Botany of Desire
“Much has been written about prions and Mad Cow Disease–nearly all of it is worthless. Thankfully, from the world of journalism comes D.T. Max to set things right. Throw all those other “Mad Cow” books in the trash: This is the book to read about prions–or whatever you want to call them. It’s a riveting tale, told by someone with a very special understanding, derived in part from his own strange ailment. Find a cozy spot, clear your schedule and dive in.”
– Laurie Garrett, author of Betrayal of Trust and The Coming Plague
“D. T. Max deftly unfolds the mysterious prion in all its villainous guises. Although scientists do not fully understand these proteins–how they replicate and wreak such havoc in their victims’ brains–The Family That Couldn’t Sleep reveals their historical, cultural, and scientific place in our world. Prepare to be enlightened, entertained, and frightened.”
–Katrina Firlik, MD, author of Another Day in the Frontal Lobe
“A great book. D.T. Max has drawn the curtain on a cabinet of folly and malady that will stagger your imagination.”
– Philip Weiss, author of American Taboo
“D.T. Max has combined the enthralling medical anthropology of Oliver Sacks with the gothic horror of Stephen King to produce a medical detective story that is as intelligent as it is spooky. The villain of The Family That Couldn’t Sleep is the prion, a tiny little protein that causes some of the most terrifying, brain-mangling, creepy diseases known to man. Always fascinating–how could it not be, given that its characters include cannibals, mad cows, madder sheep, a Nobel prize-winning pedophile, and, most poignantly, an Italian family cursed by fatal insomnia?–Max’s book is also a gripping account of scientific discovery, and a heartfelt meditation on what it means to be cursed with an incurable, and brutal, illness.” – David Plotz, author of The Genius Factory
The stories read like Outer Limits plots: A Stone Age tribe in Papua New Guinea is decimated by a mysterious illness that afflicts its victims with laughter and then death. A noble Venetian family dynasty is cursed by a disease that turns them into insomniacs. Thousands of wild deer perish of starvation in high fields of grass. Unfortunately, these Ripley's Believe or Not-worthy episodes possess more than passing interest; they signal the advance guard of diseases that may lurk as time bombs around the globe. D. T. Max's The Family That Couldn't Sleep can be read as a fascinating study of brain proteins and neurological diseases or as a full-blast medical wake-up call.
In this gripping, cleanly written, cannily plotted and elegantly educational book, D. T. Max shows us what happens when the insomnia isn't ordinary and doesn't end, no matter how aggressive the medical intervention or generous the sedative prescription…the book brims with great tales, some tragic, others cautionary.
The New York Times
An engaging nonfiction "medical mystery" starts with the strange case of an Italian family whose members, upon reaching a certain age, succumb to a sort of sleeping disorder that causes not only insomnia but certain death. The cause of this disease is determined to be prions—infectious agents derived from proteins, not viruses—so Max explores other prion diseases, such as mad cow disease and kuru, and delves into the history of prion research as a way of unraveling the mysteries behind the disease that's been plaguing the titular family for generations. Gardner lets the material do most of the heavy lifting by narrating in a plain, unadorned style that keeps his own contributions to the narrative minimal, the auditory equivalent of transparent prose. The pacing and fascinating subject matter keep the listener fully engaged throughout, resulting in an audiobook that will certainly be no cure for insomnia. In fact, it might even warrant an advisory warning: side effects may include sleepless nights, caused by a strong desire to get to the next chapter. Simultaneous release with the Random House hardcover (Reviews, July 31). (Nov.)Copyright 2007 Reed Business Information