Fundamentals of Molecular Structural Biology

by Subrata Pal PhD

Overview

Fundamentals of Molecular Structural Biology reviews the mathematical and physical foundations of molecular structural biology. Based on these fundamental concepts, it then describes molecular structure and explains basic genetic mechanisms. Given the increasingly interdisciplinary nature of research, early career researchers and those shifting into an adjacent field often require a "fundamentals" book to get them up-to-speed on the foundations of a particular field. This book fills that niche. - Provides a current and easily digestible resource on molecular structural biology, discussing both foundations and the latest advances - Addresses critical issues surrounding macromolecular structures, such as structure-based drug discovery, single-particle analysis, computational molecular biology/molecular dynamic simulation, cell signaling and immune response, macromolecular assemblies, and systems biology - Presents discussions that ultimately lead the reader toward a more detailed understanding of the basis and origin of disease

Product Details

ISBN-13:	9780128148563
Publisher:	Elsevier Science & Technology Books
Publication date:	08/13/2019
Sold by:	Barnes & Noble
Format:	eBook
Pages:	518
File size:	174 MB
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About the Author

Subrata Pal obtained his bachelor's and master's degrees, both in physics, from Calcutta University. Subsequently, he pursued his predoctoral research in molecular biology and received a PhD degree from the same university in 1982. He carried out his postdoctoral research in DNA replication and gene expression at two of the premiere institutions in the USA: the National Institutes of Health, Bethesda, Maryland and Harvard Medical School, Boston Massachusetts. At Harvard, he received a Claudia Adams Barr special investigator award for basic contribution to cancer research. Professor Pal has a long teaching experience at the undergraduate and graduate levels – the areas of his teaching include physics, molecular biology and genomics.
Subrata Pal obtained his bachelor’s and master’s degrees, both in physics, from Calcutta University. Subsequently, he pursued his predoctoral research in molecular biology and received a PhD degree from the same university in 1982. He carried out his postdoctoral research in DNA replication and gene expression at two of the premiere institutions in the USA: the National Institutes of Health, Bethesda, Maryland and Harvard Medical School, Boston Massachusetts. At Harvard, he received a Claudia Adams Barr special investigator award for basic contribution to cancer research. Professor Pal has a long teaching experience at the undergraduate and graduate levels – the areas of his teaching include physics, molecular biology and genomics.

Table of Contents

1. Introduction - A historical perspective2. Mathematical tools3. Physical basis of chemistry4. Chemical basis of biology5. Biomacromolecules6. Structure analysis and visualization7. Protein folding8. DNA synthesis: Replication9. Transcription10. RNA processing11. Translation12. DNA damage and repair13. Recombination14. Membrane structure and function15. Fundamentals of structural genomics16. Cell signaling and systems biology17. Macromolecular assemblies18. Computational molecular biology

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From the Publisher

With coverage from mathematical and physical concepts to macromolecular structures and genetic mechanisms, this book comprehensively covers molecular structural biology