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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins

By Raphael Enoque Ferraz de Paiva
eBook
$99.00
By Raphael Enoque Ferraz de Paiva
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This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N N and C N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility cou...

Categories

Science & TechnologyChemistryInorganic Chemistry