Handbook of Cannabis

Handbook of Cannabis

by Roger Pertwee (Editor)

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Overview

Truly global in scope and with contributions from leading researchers around the world, The Handbook of Cannabis is the definitive resource on this fascinating drug. Combining scientific perspectives and clinical applications, it covers a vast array of topics, from why over the centuries cannabis has been used as a medicine, through the regulations facing those wishing to self-administer cannabis or provide cannabis-based medicines, to the chemical structure of its many constituents and the rapidly growing group of synthetic cannabinoids that are currently being used for 'legal highs'.

With each chapter written by a group of one or more internationally recognised subject experts, it provides academics and researchers with authoritative scientific material on the main pharmacological actions and their effects, as well as their pharmacokinetics, metabolism, and forensic detection. In addition it also examines the complex morphology, cultivation, harvesting, and processing of cannabis and the ways in which the plant's chemical composition can be controlled.

As well as offering a raft of scientific information there is extensive coverage of cannabinoid-based medicines. Helping readers to identify and evaluate their benefits, chapters explore pharmacological actions and the effects that seem to underlie approved therapeutic uses, how they are currently used to treat certain disorders, and the ever-growing number of wide-ranging potential clinical applications. There is also coverage of both the legal and illegal sources of cannabis, including 'coffee shops' and 'cannabis dispensaries'.

The complex issue of 'recreational cannabis' is also tackled. The sought-after and adverse psychological and non-psychological effects are described and discussions are included on how some adverse effects can be lessened by at least one constituent of cannabis, and that it might be possible to reduce the harm that cannabis does to some by changing current regulatory policies.

The Handbook of Cannabis is a one-stop reference; essential reading for all clinicians, pharmacologists, psychologists, and psychiatrists interested in this drug, as well as those working in the field of public health.

Product Details

ISBN-13: 9780198792604
Publisher: Oxford University Press
Publication date: 10/01/2016
Edition description: Reprint
Pages: 784
Sales rank: 886,416
Product dimensions: 9.60(w) x 6.70(h) x 1.70(d)

About the Author

Roger Pertwee, Professor of Neuropharmacology, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, UK

Roger Pertwee has three degrees from the University of Oxford: MA (in biochemistry), D.Phil. (in pharmacology) and D.Sc. (in physiological sciences). He is Professor of Neuropharmacology at the University of Aberdeen, Director of Pharmacology for GW Pharmaceuticals, co-chairman of the International Union of Basic and Clinical Pharmacology (IUPHAR) Subcommittee on Cannabinoid Receptors, a co-ordinator of the British Pharmacological Society's Special Interest Group on Cannabinoids, and visiting Professor at the University of Hertfordshire. He has also served as chairman of the International Association for Cannabinoid Medicines (IACM; 2005-2007) and twice as President of the International Cannabinoid Research Society (ICRS; 1997-1998; 2007-2008), and is currently ICRS International Secretary and also a member of the IACM board of directors.

Table of Contents

Part 1 Constituents, History, International Control, Cultivation and Phenotypes of Cannabis Ethan B. Russo
1. Constituents of Cannabis Sativa, Mahmoud A. ElSohly and Waseem Gul
2. The Pharmacological History of Cannabis, Ethan B. Russo
3. International Control of Cannabis, Alice P. Mead
4. Cannabis Horticulture, David J. Potter
5. Cannabis Phenotypes (Chemotypes) of Cannabis, Etienne de Meijer
Part 2 Pharmacology, Pharmacokinetics, Metabolism and Forensics Roger G. Pertwee
6. Known Pharmacological Actions of Delta-9-Tetrahydrocannabinol and of Four Other Chemical Constituents of Cannabis that Activate Cannabinoid Receptors, Roger G. Pertwee and Maria Grazia Cascio
7. Known Pharmacological Actions of Nine Non-Psychotropic Phytocannabinoids, Maria Grazia Cascio and Roger G. Pertwee
8. Effects of Phytocannabinoids on Neurotransmission in the Central and Peripheral Nervous Systems, Bela Szabo
9. Cannabinoids and Addiction, Eliot L. Gardner
10. Effects of Phytocannabinoids on Anxiety, Mood, and the Endocrine System, Sachin Patel, Matthew N. Hill, and Cecilia J. Hillard.
11. Phytocannabinoids and the Cardiovascular System, Saoirse E. O'Sullivan
12. Phytocannabinoids and the Gastrointestinal System, Marnie Duncan and Angelo A. Izzo
13. Reproduction and Cannabinoids: Ups and Downs, Ins and Outs, Jordyn M. Stuart, Emma Leishman, and Heather B. Bradshaw
14. Phytocannabinoids and the Immune System, Guy A. Cabral, Erinn S. Raborn, and Gabriela A. Ferreira
15. Non-Phytocannabinoid Constituents of Cannabis and Herbal Synergy, John M. McPartland and Ethan B. Russo
16. Cannabinoid Pharmacokinetics and Disposition in Alternative Matrices, Marilyn A. Huestis and Michael L. Smith
Part 3 Medicinal Cannabis and Cannabinoids: Clinical Data Ethan B. Russo
17. Self-Medication with Cannabis, Arno Hazekamp and George Pappas
18. Cannabis Distribution: Coffee Shops to Dispensaries, Amanda Reiman
19. Development of Cannabis-Based Medicines: Regulatory Hurdles/Routes in Europe and the United States, Alison Thompson and Verity Langfield
20. Licensed Cannabis-Based Medicines: Benefits and Risks, Stephen Wright and Geoffrey Guy
21. Synthetic Psychoactive Cannabinoids Licensed as Medicines, Mark A. Ware
22. Cannabinoids in Clinical Practice: A UK Perspective, William Notcutt and Emily L. Clarke
Part 4 Approved Therapeutic Targets for Phytocannabinoids: Preclinical Pharmacology Marnie Duncan
23. Effect of Phytocannabinoids on Nausea and Vomiting, Erin M. Rock, Martin A. Sticht, and Linda A. Parker
24. Established and Emerging Concepts of Cannabinoid Action on Food Intake and their Potential Application to the Treatment of Anorexia and Cachexia, Luigia Cristino and Vincenzo Di Marzo
25. Pain, Barbara Costa and Francesca Comelli
26. Cannabis and Multiple Sclerosis, Gareth Pryce and David Baker
Part 5 Some Potential Theraputic Targets for Phytocannabinoids Marnie Duncan
27. Neurodegenerative Disorders Other Than Multiple Sclerosis, Javier Fernandez-Ruiz, Eva de Lago, Maria Gomez-Ruiz, Concepcion Garcia, Onintza Sagredo, and Moises Garcia-Arencibia
28. Cannabidiol/Phytocaanabinoids: A New Opportunity for Schizophrenia Treatment, Daniela Parolaro, Erica Zamberletti and Tiziana Rubino
29. Phytocannabinoids as Novel Therapeutic Agents for Sleep Disorders, Eric Murillo-Rodriguez, Lisa Aguilar-Turton, Stephanie Mijangos-Moreno, Andrea Sarro-Ramirez, and Oscar Arias-Carrion
30. Cannabis and Epilepsy, Claire M. Williams, Nicholas A. Jones and Benjamin J. Whalley
31. Cardiovascular, Metabolic, Liver, Kidney, and Inflammatory Disorders, Pal Pacher and George Kunos
32. Phytocannabinoids and Skin Disorders, Sergio Oddi and Mauro Maccarrone
33. Phytocannabinoids in Degenerative and Inflammatory Retinal Diseases: Glaucoma, Age-Related Macular Degeneration, Diabetic Retinopathy and Uveoretinitis, Heping Xu and Augusto Azuara-Blanco
34. Bone As a Target for Cannabinoid Therapy, Itai Bab
35. Cancer, Guillermo Velasco, Cristina Sanchez, and Manuel Guzman
Part 6 Recreational Cannabis: Sought-After Effects, Adverse Effects, Designer Drugs and Harm Minimization Wayne Hall
36. Desired and Undesired Effects of Cannabis on the Human Mind and Psychological Well-Being, H. Valerie Curran and Celia J. A. Morgan
37. Recreational Cannabis: The Risk of Schizophrenia, Paul D. Morrison, Sagnik Bhattacharyya, and Robin M. Murray
38. Nonpsychological Adverse Effects, Franjo Grotenhermen
39. Harm Reduction Policies for Cannabis, Wayne Hall and Louisa Degenhardt
40. Cannabinoid Designer Drugs: Effects and Forensics, Brian F. Thomas, Jenny L. Wiley, Gerald T. Pollard, and Megan Grabenauer

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