Immunotherapy and Biomarkers in Neurodegenerative Disorders

by Martin Ingelsson, Lars Lannfelt

Overview

This practical volume examines a number of topics that explore the current status of immunotherapy and diagnostic markers for neurodegenerative disorders. With a focus on Alzheimer’s disease, the first sections of the book examine immunotherapeutic approaches for the aforementioned disease as well as for Parkinson’s disease and Huntington’s disease,
amongst others. The last section of the book covers the importance of biomarker techniques to catch these diseases early enough for the treatments to be most useful. Written for the Methods in
Pharmacology and Toxicology series, this book contains the kind of detailed descriptions and implementation advice that will offer a smooth transition into the lab.

Authoritative and useful, Immunotherapy and Biomarkers in
Neurodegenerative Disorders aims to aid in the continued progress in the development of novel immune-based drugs and diagnostic tools for these devastating brain diseases.

Product Details

ISBN-13:	9781493980789
Publisher:	Springer New York
Publication date:	04/19/2018
Series:	Methods in Pharmacology and Toxicology
Edition description:	Softcover reprint of the original 1st ed. 2016
Pages:	289
Product dimensions:	7.01(w) x 10.00(h) x (d)

Table of Contents

Part I: Immunotherapy
Against Amyloid-b in
Alzheimer’s Disease

1. Immunotherapy Against Amyloid-β in Alzheimer’s Disease: An Overview

Niels D. Prins

2. Active Immunization Against the
Amyloid-β Peptide

Enchi Liu and J. Michael Ryan

3. Immunotherapy
Against N-Truncated Amyloid-β Oligomers

Thomas A.
Bayer and Oliver Wirths

4. Immunotherapy
Against Amyloid-β Protofibrils: Opportunities and Challenges

Lars
Lannfelt

Part II:
Immunotherapy in Other Neurodegenerative Disorders

5. Immunotherapy
Against α-Synuclein Pathology

Elvira
Valera and Eliezer Masliah

6. Extracellular α-Synuclein as a Target for
Immunotherapy

Jun Sung Lee and Seung-Jae Lee

7. Immunotherapy of Parkinson’s Disease

Achim Schneeberger,
Suzanne Hendrix, and Markus Mandler

8. Tau Immunotherapy

Einar M. Sigurdsson

9. Active and Passive Immunotherapy Against Tau: Effects and
Potential Mechanisms

Kiran Yanamandra, Marc
I. Diamond, and David M. Holtzman

10. Immunotherapy on Experimental Models for
Huntington’s Disease

Anne Messer

Part III: Biomarkers for Neurodegenerative Disorders

11. Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease

Henrik Zetterberg and
Jonathan M. Schott

12. Volumetric MRI as a Diagnostic Tool in
Alzheimer's Disease

Eric Westman, Lena Cavalin, and
Lars-Olof Wahlund

13. PET Imaging as a Diagnostic Tool in Alzheimer's
Disease

Juha O. Rinne

14. Αlpha-Synuclein as a Diagnostic
Biomarker for Parkinson’s Disease

Joakim Bergström and Martin Ingelsson

15. Imaging as a Diagnostic Tool in
Parkinson’s Disease

Johan Wikström and Torsten Danfors

16. Mass
Spectrometry-Based Proteomics in Biomarker Discovery for Neurodegenerative
Diseases

Sravani Musunuri,
Ganna Shevchenko, and Jonas Bergquist